ID   MUTS_GEOSL              Reviewed;         871 AA.
AC   P61667;
DT   07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2004, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=GSU1822;
OS   Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfuromonadales;
OC   Geobacteraceae; Geobacter.
OX   NCBI_TaxID=243231;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51573 / DSM 12127 / PCA;
RX   PubMed=14671304; DOI=10.1126/science.1088727;
RA   Methe B.A., Nelson K.E., Eisen J.A., Paulsen I.T., Nelson W.C.,
RA   Heidelberg J.F., Wu D., Wu M., Ward N.L., Beanan M.J., Dodson R.J.,
RA   Madupu R., Brinkac L.M., Daugherty S.C., DeBoy R.T., Durkin A.S.,
RA   Gwinn M.L., Kolonay J.F., Sullivan S.A., Haft D.H., Selengut J.,
RA   Davidsen T.M., Zafar N., White O., Tran B., Romero C., Forberger H.A.,
RA   Weidman J.F., Khouri H.M., Feldblyum T.V., Utterback T.R., Van Aken S.E.,
RA   Lovley D.R., Fraser C.M.;
RT   "Genome of Geobacter sulfurreducens: metal reduction in subsurface
RT   environments.";
RL   Science 302:1967-1969(2003).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AE017180; AAR35199.1; -; Genomic_DNA.
DR   RefSeq; NP_952872.1; NC_002939.5.
DR   RefSeq; WP_010942467.1; NC_002939.5.
DR   AlphaFoldDB; P61667; -.
DR   SMR; P61667; -.
DR   STRING; 243231.GSU1822; -.
DR   EnsemblBacteria; AAR35199; AAR35199; GSU1822.
DR   KEGG; gsu:GSU1822; -.
DR   PATRIC; fig|243231.5.peg.1859; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_7; -.
DR   InParanoid; P61667; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000000577; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0030983; F:mismatched DNA binding; IBA:GO_Central.
DR   GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..871
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115099"
FT   BINDING         621..628
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   871 AA;  95906 MW;  63564ED19635A2BF CRC64;
     MSELTPMMRQ YLEIKADHPD AILFFRLGDF YEMFLDDAVK ASRILDITLT SRNKGGDGAD
     IPLCGVPFHS AAPYIAKLVE AGEKVAICEQ VEDPKSVKGI VKREVVKVVT PGLVIDAESL
     SPKENNYLLS LFPGPDRWGV AYLDLSTGDF RVTETDSADA AWAEVACVNP REILMPLSFR
     DGGAGSERPD LAAGRMLSYV DEWVYDAEYA ERMVRNHFGV ASAEAAGCGS MDCGLRAVAA
     VLHYLQQTQK GDVRHISYLQ AYRTQEFLVL DESSRRNLEL NATIGDGKRR GSLLGLLDRT
     VTAMGGRKLK QWINYPLVSI EKINERLDAV EELVADAEFR QGVRAALDGV YDLERLNGRI
     SLASASAKDL VALRASLVRL PSLIALLTPA ASTLLARLRD GIDLLADVEE LIGRGIVPDP
     PFVLREGGII AQGYHSELDE LRSISREGKG FIARLEAQEK ARTGISSLKV RYNKVFGYYI
     EVTKSNLSAI PDDYIRRQTL ANAERFITPE LKEYEEKVLG AEDRIVELEY ALFQDIRQRV
     AAQGERIART ADRLATLDVL AALADVAHDH RYVRPTVDEG DAIVVTGGRH PVVEALNRSE
     RFVANDVQLD NGENQLVIIT GPNMAGKSTF MRQVALIVLM AQTGSFVPAD EASIGVVDRI
     FTRVGASDNL ARGQSTFMVE MMETAAILRN ATPRSLVVLD EIGRGTSTFD GVSIAWAVAE
     YLHDTERCAA KTLFATHYHE LTELAVTRNR VKNCNVAVKE WNDQVIFLRK IVEGGASHSY
     GIQVARLAGL PQEVIERAKE ILHNLEKGEY AEGGIPRIAR GKRAGAPKPS PQLSLFDQGD
     DLLRRRIAGL NIAALTPLEA LNILDELKRM V