ID   MUTS_GEOSM              Reviewed;         869 AA.
AC   C6DZZ3;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-SEP-2009, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=GM21_2495;
OS   Geobacter sp. (strain M21).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfuromonadales;
OC   Geobacteraceae; Geobacter; unclassified Geobacter.
OX   NCBI_TaxID=443144;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M21;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C.,
RA   Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G.,
RA   Lovley D.;
RT   "Complete sequence of Geobacter sp. M21.";
RL   Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP001661; ACT18537.1; -; Genomic_DNA.
DR   RefSeq; WP_015837769.1; NC_012918.1.
DR   AlphaFoldDB; C6DZZ3; -.
DR   SMR; C6DZZ3; -.
DR   STRING; 443144.GM21_2495; -.
DR   EnsemblBacteria; ACT18537; ACT18537; GM21_2495.
DR   KEGG; gem:GM21_2495; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_7; -.
DR   OMA; TPMMAQY; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..869
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000202737"
FT   BINDING         621..628
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   869 AA;  95990 MW;  D136A8C279DAF401 CRC64;
     MSEMTPMMRQ FLEIKAEHPD AILFFRCGDF YEMFLDDAVK ASRILGITLT SRNKNADGSE
     VPLCGIPYHS CAPYIAKLVE AGEKVAICEQ AEDPKQAKGI VKREVVKVIT PGLVIEDASL
     SPKENNYLLA LCCDGECYGL SYLDLSTGEF RVTELDGLQA ALAEVTCIGP REIILPVCFR
     EEPKRKEVAH VIVDRSITYF EEWVYDPDYC KRLVANQFKG ATAESLGCDR LPTALLAAGA
     VLHYLVDTQK GHAPHVTCIT PYNESEHLLL DESTRRNLEL TATLSEGKRK GSLLGLMDRT
     VTAMGGRKLK QWINYPLMDL KKIWLRQDAI QELMEAPGTR EAMKSLLAGV YDLERLNGRI
     SLASASAKDL SALRSSLSRL PAIKEQVAAC GAGLLKELDA GIDPLDELSD LISSAIVDDP
     PFVLRDGGII ADGYNQELDE LRAISREGKG FIARLEAQEK GRTGISSLKI RYNKVFGYYI
     EVTKANVSAI PDDYIRRQTL ANAERYITPE LKEYEEKVLG AEDRIKDLEF SLFQEVREAA
     AAQGERIARS ADRLACLDVL VSLSELAHDK GYCRPEVHEG SELSITEGRH PVIEDMHSAE
     RFVPNDTLLD NGENQLIIIT GPNMAGKSTF MRQVALISLM AQMGSFVPAD KALIPLVDRI
     FTRVGASDNL ARGHSTFMVE MMESAAILRG ATARSLVILD EIGRGTSTFD GVSIAWAVAE
     FLHDNKIHAA KTLFATHYHE LTELAVTRPG IKNFNIAVRE WNERIIFLRK IVPGGASHSY
     GIQVARLAGL PQAVIDRAKE ILINLEKGEY GEGGVPRLAR GKKTPPPSPQ LSLFGAGDDQ
     IRERLKEIEV ALLTPLEALN LVDELKRMI