ID   MUTS_GEOSW              Reviewed;         860 AA.
AC   C5D9H5;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=GWCH70_1202;
OS   Geobacillus sp. (strain WCH70).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus;
OC   unclassified Geobacillus.
OX   NCBI_TaxID=471223;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WCH70;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C.,
RA   Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N.,
RA   Brumm P., Mead D.A., Richardson P.;
RT   "Complete sequence of chromosome of Geopacillus sp. WCH70.";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP001638; ACS24061.1; -; Genomic_DNA.
DR   RefSeq; WP_015863533.1; NC_012793.1.
DR   AlphaFoldDB; C5D9H5; -.
DR   SMR; C5D9H5; -.
DR   STRING; 471223.GWCH70_1202; -.
DR   PRIDE; C5D9H5; -.
DR   EnsemblBacteria; ACS24061; ACS24061; GWCH70_1202.
DR   KEGG; gwc:GWCH70_1202; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_1_3_9; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..860
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000202738"
FT   BINDING         606..613
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   860 AA;  98631 MW;  0134290F4BE9A1BA CRC64;
     MATYTPMIQQ YLDIKAQYPD AFLFFRLGDF YEMFFDDAIK AAQELEITLT SRDGGGEERV
     PMCGVPYHSA QGYIEQLISK GYKVAICEQV EDPKTAKGVV RREVVQLITP GTVMEGKGLL
     DKENNYLATV TMFDDGTYGF AYTDLSTGEN RITLLASLDD VMNELYAIGT KEIVISSQFP
     EQYQQLLKER YDVTISYEDE TVIPEGFTSI VEALQQDKLK ITFGRLLHYI IRTQKRRLDH
     MQSVQVYQVD HYMKIDLYSK RNLELTETIR SKGRKGSLLW LLDETVTAMG GRLLKQWLDR
     PLLDRKQIER RLHMVETLIH HYFERQELRE RLREVYDVER LAGRVAYGNV NARDLIQLKK
     SLQQIPALKD IVEKLPDHEA KQLANKLDPC SELVDLLERS IQENPPLSVK EGNIIKDGYN
     ETLDRYRDAS RNGKAWIAQL ESKERELTGI KSLKIGYNRV FGYYIEVTKP NLHLLPKGRY
     ERKQTLANAE RFITQELKEK EALILEAEEK SIELEYELFV DIRERVKQYI PRLQSLAKTI
     SELDVLQSFA TVSEERHYVK PQFSDNRELI IQAGRHPVVE KVLGAQTYVP NDCYMNKERE
     LLLITGPNMS GKSTYMRQIA LTVIMAQIGC FVPAEKAVLP IFDQVFTRIG AADDLVSGQS
     TFMVEMLEAR NAIVHATQNS LILFDEIGRG TSTYDGMALA QAIIEYIHDH IGAKTLFSTH
     YHELTDLEQS LAKLKNVHVR AVEENGKVVF LHKIEEGPAD QSYGIHVAEL AELPASLIQR
     AKEILAELEQ QEQRKEQPSG KNEAVFEQLS MFAEEQPSKE ESHLSKKEKK ALEALKSVNL
     LETTPLEALN KLYEIQKLLK