ID   MUTS_GEOTN              Reviewed;         910 AA.
AC   A4IMI0;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=GTNG_1160;
OS   Geobacillus thermodenitrificans (strain NG80-2).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus.
OX   NCBI_TaxID=420246;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NG80-2;
RX   PubMed=17372208; DOI=10.1073/pnas.0609650104;
RA   Feng L., Wang W., Cheng J., Ren Y., Zhao G., Gao C., Tang Y., Liu X.,
RA   Han W., Peng X., Liu R., Wang L.;
RT   "Genome and proteome of long-chain alkane degrading Geobacillus
RT   thermodenitrificans NG80-2 isolated from a deep-subsurface oil reservoir.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:5602-5607(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000557; ABO66534.1; -; Genomic_DNA.
DR   AlphaFoldDB; A4IMI0; -.
DR   SMR; A4IMI0; -.
DR   STRING; 420246.GTNG_1160; -.
DR   EnsemblBacteria; ABO66534; ABO66534; GTNG_1160.
DR   KEGG; gtn:GTNG_1160; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_9; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000001578; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..910
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335160"
FT   BINDING         607..614
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   910 AA;  102704 MW;  7625930297F69A65 CRC64;
     MMPSYTPMIQ QYLHIKAQYP DAFLFFRLGD FYEMFFDDAI KAAQELEITL TSRDGGGDER
     VPMCGVPYHS AQGYIEQLVE KGYKVAICEQ VEDPKTAKGV VRREVVQLVT PGTLMEGKGL
     TEKENHYLAT LTPFADSTYG LAYADLSTGE VRLTLLSSWE ETGNELHAIG AREIVISSDS
     AEEWVRELKE RYGAAISYED ETWLRDEWSS VAGHVTQEKL RVTVARLLHY LVRTQKRQLD
     HLQPAELYQV DQYMKMDRHS KLHLELVETV RSKGRKGSLL WLLDETVTAM GGRLLKQWLD
     RPLIDQRAIE RRLDFVETLK TSYFERHELR DRLRDVYDIE RLVGRIAYGN ANARDLVQLK
     KSLSQVPSLR QTVSGLPLAE VDELVGRLDP CEELVDLLER AIQEQPPLSI KEGNIIKDGY
     DERLDRYRDA SRNGKAWIAE LEAKEREVTG IKSLKVGYNR VFGYYIEVTK PNLPLIPEGR
     YERKQTLANA ERFITAELKE KEALILEAEE KSVELEYELF VAIREQVKEY IPRLQTLAKA
     IAELDVLQAL ATVSDERRYV RPQFSTERVL AIEGGRHPVV EKVLGAQTYV PNDCYMNRER
     EMLLITGPNM AGKSTYMRQV ALTAIMAQIG CFVPAERAVL PIFDQVFTRI GAADDLSAGQ
     STFMVEMLEA RRAITHATQN SLILFDEIGR GTSTYDGMAL AQAMIEYIHD HIGAKTLFST
     HYHELTALES SLERLCNVHA RAVEENGKVV FLHQIADGPA DRSYGIHVAE LAGLPISLIE
     RARDILAKLE QSSGNGSLEQ GIGEEAGREN GSLMEAASQQ QSELELTVGS AADRVVEQSV
     ERQAEHRASA GNEASFEQLS MFPDLAPAPV EPHLSSKEKK ALAALKEVNL LEMTPLEALN
     KLYELQKLLK