ID   MUTS_GEOUR              Reviewed;         872 AA.
AC   A5G447;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Gura_2386;
OS   Geotalea uraniireducens (strain Rf4) (Geobacter uraniireducens).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfuromonadales;
OC   Geobacteraceae; Geotalea.
OX   NCBI_TaxID=351605;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1134 / JCM 13001 / Rf4;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Mikhailova N., Shelobolina E., Aklujkar M.,
RA   Lovley D., Richardson P.;
RT   "Complete sequence of Geobacter uraniireducens Rf4.";
RL   Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000698; ABQ26565.1; -; Genomic_DNA.
DR   RefSeq; WP_011939257.1; NC_009483.1.
DR   AlphaFoldDB; A5G447; -.
DR   SMR; A5G447; -.
DR   STRING; 351605.Gura_2386; -.
DR   EnsemblBacteria; ABQ26565; ABQ26565; Gura_2386.
DR   KEGG; gur:Gura_2386; -.
DR   HOGENOM; CLU_002472_3_1_7; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000006695; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..872
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335161"
FT   BINDING         622..629
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   872 AA;  96488 MW;  DF9825381CF3632B CRC64;
     MSQLTPMMRQ YLEIKAGYPD AILFFRLGDF YEMFLDDAVK ASRILDITLT SRNKNSDGAD
     VPLCGIPYHS ATPYIAKLIE AGEKVAICEQ VEDPKSVKGI VRREVVKVIT PGLVVDSSNL
     SPKENNYLLS LYCDDATTWG LSYLDLSTGE FRVTELDGFD AAVAEVACVK PREIILPAVF
     RENGRMKELM PVTAGLATTF VDDWVYDLDY CKRLIGSHFG GASPSALGCD GLNTGLYAIC
     AVLHYLQETQ KGRAGHVNSI IPYTNREYLV LDESTRRNLE LTATLAEGKR KGSLLGLMDR
     TTTAMGGRKM KQWINYPLVT IQSITERQDA IEEFVQDPSR RTALVFLLNG VYDLERLNGR
     ISLASAGAKD LVAMKESLAR IPGIKELLAS SSSVLLRRLN EGLNPLPDLV GLIAGGIVEN
     PPFVLRDGGI IADGYNAELD ELRAISREGK GFIARLEAQE KGRTGINSLK IRYNKVFGYY
     IEVTKTNLTS IPADYIRKQT LANAERYITP ELKEYEDKVL GAEDRIRELE FSLFQEIRET
     VTGHGEIVAR TADCLATLDV LASLAELAHE RNYCRPLVDD GTTLFISEGR HPVIEAMHQG
     ERFVPNDTLL DNGENQLIII TGPNMAGKST FMRQVALITL MAQMGSFVPA TEAHISLVDR
     IFTRVGASDN LARGQSTFMV EMMESANILR HATPKSLVIL DEIGRGTSTF DGVSIAWAVA
     EFLHDNDKHA AKTLFATHYH ELTELAVTRK RIKNFNIAVK EWNEQIIFLR KIVSGGASHS
     YGIQVARLAG LPLEVIERAK EILQNLEKGE FAEEGIPRIA RGKKSAGSAP ASQLSLFDSG
     EDMLRKRLKG MDVTTLTPLE ALNLLDELKR MV