ID   MUTS_GLOVI              Reviewed;         890 AA.
AC   Q7NLT8;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=gll1033;
OS   Gloeobacter violaceus (strain ATCC 29082 / PCC 7421).
OC   Bacteria; Cyanobacteria; Gloeobacteria; Gloeobacterales; Gloeobacteraceae;
OC   Gloeobacter.
OX   NCBI_TaxID=251221;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29082 / PCC 7421;
RX   PubMed=14621292; DOI=10.1093/dnares/10.4.137;
RA   Nakamura Y., Kaneko T., Sato S., Mimuro M., Miyashita H., Tsuchiya T.,
RA   Sasamoto S., Watanabe A., Kawashima K., Kishida Y., Kiyokawa C., Kohara M.,
RA   Matsumoto M., Matsuno A., Nakazaki N., Shimpo S., Takeuchi C., Yamada M.,
RA   Tabata S.;
RT   "Complete genome structure of Gloeobacter violaceus PCC 7421, a
RT   cyanobacterium that lacks thylakoids.";
RL   DNA Res. 10:137-145(2003).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BA000045; BAC88974.1; -; Genomic_DNA.
DR   RefSeq; NP_923979.1; NC_005125.1.
DR   RefSeq; WP_011141035.1; NC_005125.1.
DR   AlphaFoldDB; Q7NLT8; -.
DR   SMR; Q7NLT8; -.
DR   STRING; 251221.35211596; -.
DR   EnsemblBacteria; BAC88974; BAC88974; BAC88974.
DR   KEGG; gvi:gll1033; -.
DR   PATRIC; fig|251221.4.peg.1058; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_3; -.
DR   InParanoid; Q7NLT8; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   PhylomeDB; Q7NLT8; -.
DR   Proteomes; UP000000557; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0030983; F:mismatched DNA binding; IBA:GO_Central.
DR   GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..890
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115100"
FT   BINDING         685..692
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   890 AA;  98383 MW;  4738F818BDE4A6AE CRC64;
     MADPATQLSQ WDFRRFARSD LTPMLQQYVE VKAQHPHCLL LYRMGDFYET FLADAEIVSR
     ELEIVLTGRQ AGDKIGRIPM AGIPHHALER YCAQLIEKGY AVVICDQVES PEQAKERARQ
     AKVARRSKSD GDAPLLPLLL EDGEQIDWEG AESVLVRRAV TRVLTPGTVL EDQLLVGRRN
     NYLAALVQAG ECWGLAFADI STGEFQVTQL ESAEALVQEL LRLQPAEVLL SGDAPDPLVL
     LRPGEASSER PECLPSQFCY TLRPRRYFEL DEARRLLMET FGVRSLEGFG CENLPLAVRA
     AGGLVQHLLE TQRGVSIPLE GIRTYTLSQY LILDHQTRRN LELTQTVRDG AQYGSLLWAL
     DRTRTVMGGR ALRRWLLQPL LDTRAIGRRQ DSVAELYDEG LLRERLQRIL ESVYDLERLA
     GRCGSGTANA RDLVALGESL LKLPALAEAV AASTSPYLKA LQSIPVELER LGEKLRRTLV
     DTPPLILTEG GLIRAGVHPE LEGMRGQLIE DRDWLVDLEA RERARTGIQT LKVGFNKAFG
     YYLSISRGKA EKAPPEYLRK QTLTNEERYI TPELKERETR ILNAQQQTNQ LEYDIFNILR
     QEAGRHVSAL RQVARRVAAL DALAGLAEVA VYHDYCRPVL GEGREVHIEA GRHPVIEQAI
     PAGFFVPNDA RMGAEAEPDL IILTGPNMSG KSSFIRQVAL IQLLAQVGAF VPARGAVLGV
     ADRIFTRVGA VDDLATGQST FMVEMTETAN ILNHATPRSL VLLDEIGRGT ATFDGLAIAW
     AVAEYLASHI RCRTIFATHY HELNELASVV SGVANYQVTV QELADRIVFL HRVTPGGADR
     SYGIEVGRLA GLPPSVVARA RTVLAQVEQH SQIAVGLRDS NGSASESAAG