ID   MUTS_GRABC              Reviewed;         926 AA.
AC   Q0BV38;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   OrderedLocusNames=GbCGDNIH1_0416;
OS   Granulibacter bethesdensis (strain ATCC BAA-1260 / CGDNIH1).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodospirillales;
OC   Acetobacteraceae; Granulibacter.
OX   NCBI_TaxID=391165;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1260 / CGDNIH1;
RX   PubMed=17827295; DOI=10.1128/jb.00793-07;
RA   Greenberg D.E., Porcella S.F., Zelazny A.M., Virtaneva K., Sturdevant D.E.,
RA   Kupko J.J. III, Barbian K.D., Babar A., Dorward D.W., Holland S.M.;
RT   "Genome sequence analysis of the emerging human pathogenic acetic acid
RT   bacterium Granulibacter bethesdensis.";
RL   J. Bacteriol. 189:8727-8736(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000394; ABI61314.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q0BV38; -.
DR   SMR; Q0BV38; -.
DR   STRING; 391165.GbCGDNIH1_0416; -.
DR   EnsemblBacteria; ABI61314; ABI61314; GbCGDNIH1_0416.
DR   KEGG; gbe:GbCGDNIH1_0416; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_5; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000001963; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..926
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335163"
FT   REGION          16..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         658..665
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   926 AA;  99652 MW;  3001E4479E4BA448 CRC64;
     MLAEKMGAIT LHCMPVASTP TRRGRPPGSS AARASNGAGS EAATAIPAGA TPAMAQWFVL
     KNQHPDALLF FRMGDFYELF FQDAENAAAT LDIQLTKRGL HEGEPIPMCG VPVHAAEMYL
     SRLIRRGWRV AIVEQMENPK NRAGKGPIRR DVVRLVTPGT ITEETLLDAG RPNLLLAITQ
     SGNRLGAAWL DISTGLFETE SLDESGLTAL LGRLDPAEIL CPSSLHLEMW DARRGPEQPV
     SDPANARARL AEAYDVSHIN VFGSFTDAEA MAAMQALDYV RDAQMGALPR LGHPVPVGEA
     GRLAMDASTR ASLEIDRARD GGTERTLLSA VQRTLTPAGG RMLAAWLGAP LTDRTVITAR
     QDGWGWLLEQ PTLSMRLRET LRGCPDMARA LGRIALGRGT PRDLAAIRDG AHIAMEAAGL
     LEGILPSALA ELHAALHLPP DLPEMLEAAL ADPVPARIED GGVIASGFDG ELDAERGLRD
     DSRKVIAALQ TEYAQRYGVA SLKIRHHAQL GYMIEVPAVA VETLRTVPEL ILRQGMANGA
     RFTHPDLSEL DRRITEAAER ARQREMIVIT ALRQKVEAHA GSIAACAEAL ARLDVLQSAA
     RLAESGTWCR PVMTDDQTLT IEAGRHPVVE AALEGGPTPF MPNDTDLSAS RRVMLLTGPN
     MAGKSTYLRQ NALIVILAQA GLPVPARAAH IGIVDRLFSR VGASDDLARG QSTFMVEMTE
     TAAILHQAGP RSLVVVDEIG RGTSTLDGLA IAWAVLEALH SRIGARTIFA THFHELARLQ
     GELPMLRPYT MKVQEWRGKV VFLHEVAEGA GGRSWGVHVA KLAGVPAATV RRAGQLLTAL
     EERSVGLTDN ATLPLFAASH GNETETEPAE GIHEAKPASL PPELIEALGQ MEPDKLTPRE
     ALDLMYHFKS MLSSQAHNGD VEAESW