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MUTS_GRAFK
ID   MUTS_GRAFK              Reviewed;         871 AA.
AC   A0LXZ7;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=GFO_0254;
OS   Gramella forsetii (strain KT0803).
OC   Bacteria; Bacteroidetes; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Gramella.
OX   NCBI_TaxID=411154;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KT0803;
RX   PubMed=17107561; DOI=10.1111/j.1462-2920.2006.01152.x;
RA   Bauer M., Kube M., Teeling H., Richter M., Lombardot T., Allers E.,
RA   Wuerdemann C.A., Quast C., Kuhl H., Knaust F., Woebken D., Bischof K.,
RA   Mussmann M., Choudhuri J.V., Meyer F., Reinhardt R., Amann R.I.,
RA   Gloeckner F.O.;
RT   "Whole genome analysis of the marine Bacteroidetes'Gramella forsetii'
RT   reveals adaptations to degradation of polymeric organic matter.";
RL   Environ. Microbiol. 8:2201-2213(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CU207366; CAL65242.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0LXZ7; -.
DR   SMR; A0LXZ7; -.
DR   STRING; 411154.GFO_0254; -.
DR   PRIDE; A0LXZ7; -.
DR   EnsemblBacteria; CAL65242; CAL65242; GFO_0254.
DR   KEGG; gfo:GFO_0254; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_10; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000000755; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..871
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335162"
FT   BINDING         618..625
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   871 AA;  98449 MW;  4B6E5556AD3BFF83 CRC64;
     MAAKKSQKVT PLMQQYNSIK LKYPDAMLLF RVGDFYETFG EDAVKAARIL NIVLTNRNNG
     GERTELAGFP HHSLNTYLPK LVKAGQRVAI CDQLEDPKMT KTIVKRGVTE LVTPGVAMND
     DILNSKSNNF LCAVHFGKKN LGVSFLDVST GEFLCAQGNT EYIDKLLQNF GPSEILVQKK
     FKKEFNESFG KDKHCFYLDD WIFKIDYSEE TLNAHFQTKS LKGFGIDHLE EGIIASGAVL
     YYLAETRHHR LQHINSINRI AEEQYVWMDR FTIRNLELYH STAANAVTLL DVIDKTISPM
     GGRLLKRWLA LPLKDAEMIE KRLQVVDFLI KNPEILANIQ DQIREISDLE RLISKVATQK
     ISPREVNQLK NSLNAIIPVK ELALKCNNEA LKIIGDNLHS CDLLREKISE SISEDAPVLI
     QRGGVIASGF SSELDELRGL AFSGKDYLDK MIQRETEKTG ISSLKIGSNN VYGYYIEVRN
     THKDKVPEEW TRKQTLVNAE RYITEELKEY ESKILGAEEK ILHLEQELFG KLIAWMAEYI
     DPVQQNARLI ARLDCLCSFA QQAQAENYSK PEITDSYGMD IEEGRHPVIE KQLPPGEVYV
     TNNLHLDREE QQIIMITGPN MSGKSAILRQ TALIVLMAQM GSFVPARSAE IGLVDKIFTR
     VGASDNISMG ESTFMVEMNE TASILNNISD RSLVLLDEIG RGTSTYDGIS IAWAISEYLH
     EHPAKPKTLF ATHYHELNEM CETFERIKNF NVSVKELKDN VLFLRKLVPG GSEHSFGIHV
     AKMAGMPQMV LHRANKILAK LEASHSMEDS GAVLKKSAED EMQLSFFNLD DPLLEDLKQE
     LLGIDIDTLT PVEALMKLNE IKRMLGNNKQ Q
 
 
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