MUTS_GRAFK
ID MUTS_GRAFK Reviewed; 871 AA.
AC A0LXZ7;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 12-DEC-2006, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=GFO_0254;
OS Gramella forsetii (strain KT0803).
OC Bacteria; Bacteroidetes; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Gramella.
OX NCBI_TaxID=411154;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KT0803;
RX PubMed=17107561; DOI=10.1111/j.1462-2920.2006.01152.x;
RA Bauer M., Kube M., Teeling H., Richter M., Lombardot T., Allers E.,
RA Wuerdemann C.A., Quast C., Kuhl H., Knaust F., Woebken D., Bischof K.,
RA Mussmann M., Choudhuri J.V., Meyer F., Reinhardt R., Amann R.I.,
RA Gloeckner F.O.;
RT "Whole genome analysis of the marine Bacteroidetes'Gramella forsetii'
RT reveals adaptations to degradation of polymeric organic matter.";
RL Environ. Microbiol. 8:2201-2213(2006).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR EMBL; CU207366; CAL65242.1; -; Genomic_DNA.
DR AlphaFoldDB; A0LXZ7; -.
DR SMR; A0LXZ7; -.
DR STRING; 411154.GFO_0254; -.
DR PRIDE; A0LXZ7; -.
DR EnsemblBacteria; CAL65242; CAL65242; GFO_0254.
DR KEGG; gfo:GFO_0254; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_3_1_10; -.
DR OMA; TPMMAQY; -.
DR Proteomes; UP000000755; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.420.110; -; 1.
DR Gene3D; 3.40.1170.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361; PTHR11361; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; SSF48334; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF53150; SSF53150; 1.
DR SUPFAM; SSF55271; SSF55271; 1.
DR TIGRFAMs; TIGR01070; mutS1; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT CHAIN 1..871
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_0000335162"
FT BINDING 618..625
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 871 AA; 98449 MW; 4B6E5556AD3BFF83 CRC64;
MAAKKSQKVT PLMQQYNSIK LKYPDAMLLF RVGDFYETFG EDAVKAARIL NIVLTNRNNG
GERTELAGFP HHSLNTYLPK LVKAGQRVAI CDQLEDPKMT KTIVKRGVTE LVTPGVAMND
DILNSKSNNF LCAVHFGKKN LGVSFLDVST GEFLCAQGNT EYIDKLLQNF GPSEILVQKK
FKKEFNESFG KDKHCFYLDD WIFKIDYSEE TLNAHFQTKS LKGFGIDHLE EGIIASGAVL
YYLAETRHHR LQHINSINRI AEEQYVWMDR FTIRNLELYH STAANAVTLL DVIDKTISPM
GGRLLKRWLA LPLKDAEMIE KRLQVVDFLI KNPEILANIQ DQIREISDLE RLISKVATQK
ISPREVNQLK NSLNAIIPVK ELALKCNNEA LKIIGDNLHS CDLLREKISE SISEDAPVLI
QRGGVIASGF SSELDELRGL AFSGKDYLDK MIQRETEKTG ISSLKIGSNN VYGYYIEVRN
THKDKVPEEW TRKQTLVNAE RYITEELKEY ESKILGAEEK ILHLEQELFG KLIAWMAEYI
DPVQQNARLI ARLDCLCSFA QQAQAENYSK PEITDSYGMD IEEGRHPVIE KQLPPGEVYV
TNNLHLDREE QQIIMITGPN MSGKSAILRQ TALIVLMAQM GSFVPARSAE IGLVDKIFTR
VGASDNISMG ESTFMVEMNE TASILNNISD RSLVLLDEIG RGTSTYDGIS IAWAISEYLH
EHPAKPKTLF ATHYHELNEM CETFERIKNF NVSVKELKDN VLFLRKLVPG GSEHSFGIHV
AKMAGMPQMV LHRANKILAK LEASHSMEDS GAVLKKSAED EMQLSFFNLD DPLLEDLKQE
LLGIDIDTLT PVEALMKLNE IKRMLGNNKQ Q