ID   MUTS_HAEDU              Reviewed;         866 AA.
AC   Q7VKA1;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=HD_2024;
OS   Haemophilus ducreyi (strain 35000HP / ATCC 700724).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=233412;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=35000HP / ATCC 700724;
RA   Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L.,
RA   Nguyen D., Wang J., Forst C., Hood L.;
RT   "The complete genome sequence of Haemophilus ducreyi.";
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AE017143; AAP96731.1; -; Genomic_DNA.
DR   RefSeq; WP_010945752.1; NC_002940.2.
DR   AlphaFoldDB; Q7VKA1; -.
DR   SMR; Q7VKA1; -.
DR   STRING; 233412.HD_2024; -.
DR   EnsemblBacteria; AAP96731; AAP96731; HD_2024.
DR   KEGG; hdu:HD_2024; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000001022; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..866
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115101"
FT   BINDING         613..620
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   866 AA;  95948 MW;  B300762B6E6011E0 CRC64;
     MNKDVSQHTP MMQQYLQLKA QHPDILLFYR MGDFYELFYE DAKKAAVLLD ISLTKRGASA
     GEPIPMAGVP YHAVEGYLAK LVALGESVAI CEQIGEVGAS KGPVERKVVR IVTPGTVSDE
     ALLPERQDNL VAAICEQKGV FAIATLDMTS GRFLISELAN KTALMAELQR VMPAEILYPE
     DFAYIPMLNN YKGLRRRPCW EFELVTAIQL LNRQFGTQCL DGFGVQQAKV ALCAAGCVLH
     YAQETQRTAL PHINSIHLSQ DSEMVLLDAA TRRNLELTQN LAGGTEATLA SVLDKCVTPM
     GSRLLKRWIH QPIRQLDILK SRQDMIATLQ QYEQIEPLQP LLRNVGDMER ILARIALRSA
     RPRDLTRLRT ALAQLPLIAK CTQNLGACLA VLLSKNADFS ELYTLLEQAI IETPPQLIRD
     GGVIAEGYHA ELDEWRTLSA GATQYLDNLE IRERESTGID TLKIGFNAVQ GYYIQISQAQ
     AHKAPIHYVR RQTLKNAERY IIPELKTYED KVLKAKGAAL ALEKQLYEQL FDLIMPHLGA
     LQQTAMALSE LDVLVNLAER AESLHYVRPS FSLQRGINIK AGRHPVVEHV MVEPFIANTV
     FLNSQRHLLI VTGPNMGGKS TYMRQTALIC LMAYIGSFVP AESAEIGVID RIFTRIGASD
     DLASGRSTFM VEMTEMANIL HQATAQSVVL IDEIGRGTST YDGLALACAC AEWLANKTQS
     LTLFATHYFE LTSLPSQLKG VANVHLDACE YNDTIAFMHS VQEGAASKSY GLAVAALAGV
     PKQVIALAKQ RLVHLEEFSQ QTKMAQQHPQ ADLLFTVEMP EEEKMAPLAK AESAVELALR
     AITPDELTPR QALDELYRLK KLLSSS