ID   MUTS_HAEI8              Reviewed;         861 AA.
AC   Q4QML2;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=NTHI0834;
OS   Haemophilus influenzae (strain 86-028NP).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=281310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=86-028NP;
RX   PubMed=15968074; DOI=10.1128/jb.187.13.4627-4636.2005;
RA   Harrison A., Dyer D.W., Gillaspy A., Ray W.C., Mungur R., Carson M.B.,
RA   Zhong H., Gipson J., Gipson M., Johnson L.S., Lewis L., Bakaletz L.O.,
RA   Munson R.S. Jr.;
RT   "Genomic sequence of an otitis media isolate of nontypeable Haemophilus
RT   influenzae: comparative study with H. influenzae serotype d, strain KW20.";
RL   J. Bacteriol. 187:4627-4636(2005).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000057; AAX87735.1; -; Genomic_DNA.
DR   RefSeq; WP_011272182.1; NC_007146.2.
DR   AlphaFoldDB; Q4QML2; -.
DR   SMR; Q4QML2; -.
DR   EnsemblBacteria; AAX87735; AAX87735; NTHI0834.
DR   KEGG; hit:NTHI0834; -.
DR   HOGENOM; CLU_002472_7_2_6; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000002525; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..861
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224375"
FT   BINDING         616..623
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   861 AA;  96450 MW;  4182667B05619868 CRC64;
     MISEENFQQH TPMMQQYLKL KAENPDILLF YRMGDFYELF YDDAKKAAAL LDISLTKRGQ
     SAGQPIPMAG MPYHAVEGYL AKLVQLGESV AICEQIGDPS TSKGPVERQI VRIVTPGTVS
     DEALLPERQD NLIAAVYQEK EKFGLATLDM TSGRFQLCEP ADKETLRAEL QRIVPVELLY
     CEEFNEMAAI EHCKGLRRRP IWEFELSTAI TLLNRQFGTK DLRAFGVEKS PLGLSAAGCL
     LQYAKETQRT ALPHIQSISL IQNQDCIQLD AATRRNLELT QNLSGGTENT LASVLDKCVT
     PMGSRLLKRW IHQPIRDVEK LKQRQQAIAE ILNFDLVDEL QPYLQLVGDM ERILARVALR
     SARPRDLTRL RTALEQIPAL RTIVQQKTSP FLTALFSQIA DFSEQWDLLQ RALIETPPLL
     IRDGGVIAEG YHAELDEWRM LSDGATQYLE NLEKREREST GIDTLKIGFN AVHGYYIQIS
     QGQAHKAPIH YVRRQTLKNA ERYIIPELKE YEDKVLKSKG AALALEKQLY DELFDLLLPH
     LGSLQLASLA LSELDVLVNL AECADTLNYV MPTFCDEVSV KIENGRHPVV EQVLKDPFIA
     NPVELNHNRH LLIITGPNMG GKSTYMRQTA LITLLAYIGS FVPADSARIG PIDRIFTRIG
     ASDDLASGRS TFMVEMTEMA NILHQATEQS LVLIDEIGRG TSTYDGLSLA WACAEWLAKK
     IRSLTLFATH YFELTALPEQ LEGIANIHLD ALEHNNSIAF MHAVQDGAAS KSYGLAVAAL
     AGVPQSVIKL AKQKLTQLEK NSSYSAEQQI QALREANHNQ GELLFEQETD ALREAIEKLD
     PDDLSPKQAL AYLYQLKKMV G