MUTS_HAEIN
ID MUTS_HAEIN Reviewed; 861 AA.
AC P44834;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=DNA mismatch repair protein MutS;
GN Name=mutS; OrderedLocusNames=HI_0707;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-62.
RC STRAIN=Eagan / Serotype B;
RX PubMed=9422600; DOI=10.1128/jb.180.1.107-118.1998;
RA Martin K., Morlin G., Smith A., Nordyke A., Eisenstark A., Golomb M.;
RT "The tryptophanase gene cluster of Haemophilus influenzae type b: evidence
RT for horizontal gene transfer.";
RL J. Bacteriol. 180:107-118(1998).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000305}.
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DR EMBL; L42023; AAC22364.1; -; Genomic_DNA.
DR EMBL; AF003252; AAB96581.1; -; Genomic_DNA.
DR PIR; G64087; G64087.
DR RefSeq; NP_438865.1; NC_000907.1.
DR RefSeq; WP_010869037.1; NC_000907.1.
DR AlphaFoldDB; P44834; -.
DR SMR; P44834; -.
DR STRING; 71421.HI_0707; -.
DR EnsemblBacteria; AAC22364; AAC22364; HI_0707.
DR KEGG; hin:HI_0707; -.
DR PATRIC; fig|71421.8.peg.737; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_4_0_6; -.
DR OMA; TPMMAQY; -.
DR PhylomeDB; P44834; -.
DR BioCyc; HINF71421:G1GJ1-740-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0030983; F:mismatched DNA binding; IBA:GO_Central.
DR GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR Gene3D; 3.30.420.110; -; 1.
DR Gene3D; 3.40.1170.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361; PTHR11361; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; SSF48334; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF53150; SSF53150; 1.
DR SUPFAM; SSF55271; SSF55271; 1.
DR TIGRFAMs; TIGR01070; mutS1; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..861
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_0000115102"
FT BINDING 616..623
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 861 AA; 96339 MW; 9F5E7FC91ABB576F CRC64;
MISEENFQQH TPMMQQYLKL KAENPDILLF YRMGDFYELF YDDAKKAAAL LDISLTKRGQ
SAGQPIPMAG MPYHAVEGYL AKLVQLGESV AICEQIGDPT TSKGPVERQI VRIVTPGTVS
DEALLPERQD NLIAAVYQEK EKFGLATLDM TSGRFQLCEP ADKETLRAEL QRIAPVELLY
CEEFNEMAAI EHCKGLRRRP IWEFELSTAI TLLNRQFGTK DLRAFGVEKS PLGLSAAGCL
LQYAKETQRT ALPHIQSISL IQNQDCIQLD AATRRNLELT QNLAGGTENT LASVLDKCVT
PMGSRLLKRW IHQPVRDVEK LKQRQQSIAE ILNFDLVDEL QPYLQLVGDM ERILARVALR
SARPRDLTRL RTALEQIPAL RAIVQQKTPP FLTALFSQIA DFSEQCDLLQ RALIETPPLL
IRDGGVIAEG YNAELDEWRM LSDGATQYLE NLEKREREST GIDTLKIGFN AVHGYYIQIS
QGQAHKAPIH YVRRQTLKNA ERYIIPELKE YEDKVLKSKG AALALEKQLY DELFDLLLPH
LGSLQLASLA LSELDVLVNL AERADTLNYV MPTFCDEVSV KIKNGRHPVV EQVLKDPFIA
NPVELNHNRH LLVITGPNMG GKSTYMRQTA LITLLAYIGS FVPADSARIG PIDRIFTRIG
ASDDLASGRS TFMVEMTEMA NILHQATAQS LVLIDEIGRG TSTYDGLSLA WACAEWLSKK
IRSLTLFATH YFELTALPEQ LEGIANIHLD ALEHNNTIAF MHAVQNGAAS KSYGLAVAAL
AGVPQSVIKL AKQKLTQLEK NSSYSAEQQI QALREANHNQ GELFFEQETD ALREAIEKLD
PDDLSPKQAL AYLYQLKKMV G
