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MUTS_HAES1
ID   MUTS_HAES1              Reviewed;         856 AA.
AC   Q0I1B8;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=HS_0005;
OS   Haemophilus somnus (strain 129Pt) (Histophilus somni).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Histophilus.
OX   NCBI_TaxID=205914;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=129Pt;
RX   PubMed=17172329; DOI=10.1128/jb.01422-06;
RA   Challacombe J.F., Duncan A.J., Brettin T.S., Bruce D., Chertkov O.,
RA   Detter J.C., Han C.S., Misra M., Richardson P., Tapia R., Thayer N.,
RA   Xie G., Inzana T.J.;
RT   "Complete genome sequence of Haemophilus somnus (Histophilus somni) strain
RT   129Pt and comparison to Haemophilus ducreyi 35000HP and Haemophilus
RT   influenzae Rd.";
RL   J. Bacteriol. 189:1890-1898(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000436; ABI24286.1; -; Genomic_DNA.
DR   RefSeq; WP_011608163.1; NC_008309.1.
DR   AlphaFoldDB; Q0I1B8; -.
DR   SMR; Q0I1B8; -.
DR   STRING; 205914.HS_0005; -.
DR   PRIDE; Q0I1B8; -.
DR   EnsemblBacteria; ABI24286; ABI24286; HS_0005.
DR   KEGG; hso:HS_0005; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..856
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000008065"
FT   BINDING         611..618
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   856 AA;  95954 MW;  BAD5DC8C3185F7D4 CRC64;
     MHTFENHTPM MKQYLKIKAE NPDVLLFYRM GDFYELFYDD AKKAAELLDI SLTKRGQSAG
     QPVPMAGVPY HAIEGYLAKL VHLGESVAIC EQVGEPVIAK GPVERQVVRI VTPGTVSDEA
     LLPEKQDNLI ATIYQEKTQF GLAVLDMTSG CFQISELQDA ASLQAELQRI QPVELLYSEA
     LEDKHLIEQF KGLRRRPLWE FELSTAIQLL NRQFGTKDLR GFGVEKAVLG LCAAGCLLQY
     AKETQRTALP HIQSISLLQN SDTVQIDAST RRNLELTQNL AGGTENTLAA ILDKCVTPMG
     SRLLKRWIHQ PIRNIEKLQC RQQHIQMLLQ QNLVEELQPL LRQVGDMERI LARVALRSAR
     PRDLTRLRTA LEQIPFIQHQ LTKIPHFVAF SQQIADFSVQ LALLQRAIID NPPLLIRDGG
     VIAEGYNEEL DEWRSLSEGA TRYLKDLEQR ERANTGIDTL KIGFNAVHGY YIQISQGQAH
     KAPLHYVRRQ TLKNAERYII PELKTYEEKV LKAKGASLAL EKQLYDEIFD QLLPHLGDLQ
     LASLTLAELD VLTNLAERAE TLNYVQPQFS TQIGLQIMQG RHPVVEQVLK DPFIANPVEL
     NQKRHLLIIT GPNMGGKSTY MRQTALITLM AYIGSFVPAE SAVIGPIDRI FTRIGASDDL
     ASGRSTFMVE MTEMANILHQ ATEQSLVLID EIGRGTSTYD GLSLAWACAE QLAQKIRSLT
     LFATHYFELT VLPEKIDGIH NVHLDAIEHN DNIAFMHSIQ EGAASKSYGL AVAALAGVPQ
     NVIKSAKQKL KQLETLSQQN SCQSQSVLTQ VQGELTLMEE EENTSAVIET LKTLDPNELS
     PKQALECLYQ LKKMLN
 
 
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