MUTS_HAES1
ID MUTS_HAES1 Reviewed; 856 AA.
AC Q0I1B8;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=HS_0005;
OS Haemophilus somnus (strain 129Pt) (Histophilus somni).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Histophilus.
OX NCBI_TaxID=205914;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=129Pt;
RX PubMed=17172329; DOI=10.1128/jb.01422-06;
RA Challacombe J.F., Duncan A.J., Brettin T.S., Bruce D., Chertkov O.,
RA Detter J.C., Han C.S., Misra M., Richardson P., Tapia R., Thayer N.,
RA Xie G., Inzana T.J.;
RT "Complete genome sequence of Haemophilus somnus (Histophilus somni) strain
RT 129Pt and comparison to Haemophilus ducreyi 35000HP and Haemophilus
RT influenzae Rd.";
RL J. Bacteriol. 189:1890-1898(2007).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000436; ABI24286.1; -; Genomic_DNA.
DR RefSeq; WP_011608163.1; NC_008309.1.
DR AlphaFoldDB; Q0I1B8; -.
DR SMR; Q0I1B8; -.
DR STRING; 205914.HS_0005; -.
DR PRIDE; Q0I1B8; -.
DR EnsemblBacteria; ABI24286; ABI24286; HS_0005.
DR KEGG; hso:HS_0005; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_4_0_6; -.
DR OMA; TPMMAQY; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.420.110; -; 1.
DR Gene3D; 3.40.1170.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361; PTHR11361; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; SSF48334; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF53150; SSF53150; 1.
DR SUPFAM; SSF55271; SSF55271; 1.
DR TIGRFAMs; TIGR01070; mutS1; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT CHAIN 1..856
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_1000008065"
FT BINDING 611..618
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 856 AA; 95954 MW; BAD5DC8C3185F7D4 CRC64;
MHTFENHTPM MKQYLKIKAE NPDVLLFYRM GDFYELFYDD AKKAAELLDI SLTKRGQSAG
QPVPMAGVPY HAIEGYLAKL VHLGESVAIC EQVGEPVIAK GPVERQVVRI VTPGTVSDEA
LLPEKQDNLI ATIYQEKTQF GLAVLDMTSG CFQISELQDA ASLQAELQRI QPVELLYSEA
LEDKHLIEQF KGLRRRPLWE FELSTAIQLL NRQFGTKDLR GFGVEKAVLG LCAAGCLLQY
AKETQRTALP HIQSISLLQN SDTVQIDAST RRNLELTQNL AGGTENTLAA ILDKCVTPMG
SRLLKRWIHQ PIRNIEKLQC RQQHIQMLLQ QNLVEELQPL LRQVGDMERI LARVALRSAR
PRDLTRLRTA LEQIPFIQHQ LTKIPHFVAF SQQIADFSVQ LALLQRAIID NPPLLIRDGG
VIAEGYNEEL DEWRSLSEGA TRYLKDLEQR ERANTGIDTL KIGFNAVHGY YIQISQGQAH
KAPLHYVRRQ TLKNAERYII PELKTYEEKV LKAKGASLAL EKQLYDEIFD QLLPHLGDLQ
LASLTLAELD VLTNLAERAE TLNYVQPQFS TQIGLQIMQG RHPVVEQVLK DPFIANPVEL
NQKRHLLIIT GPNMGGKSTY MRQTALITLM AYIGSFVPAE SAVIGPIDRI FTRIGASDDL
ASGRSTFMVE MTEMANILHQ ATEQSLVLID EIGRGTSTYD GLSLAWACAE QLAQKIRSLT
LFATHYFELT VLPEKIDGIH NVHLDAIEHN DNIAFMHSIQ EGAASKSYGL AVAALAGVPQ
NVIKSAKQKL KQLETLSQQN SCQSQSVLTQ VQGELTLMEE EENTSAVIET LKTLDPNELS
PKQALECLYQ LKKMLN