ID   MUTS_HAHCH              Reviewed;         860 AA.
AC   Q2SBR5;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 2.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=HCH_05234;
OS   Hahella chejuensis (strain KCTC 2396).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Oceanospirillales;
OC   Hahellaceae; Hahella.
OX   NCBI_TaxID=349521;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KCTC 2396;
RX   PubMed=16352867; DOI=10.1093/nar/gki1016;
RA   Jeong H., Yim J.H., Lee C., Choi S.-H., Park Y.K., Yoon S.H., Hur C.-G.,
RA   Kang H.-Y., Kim D., Lee H.H., Park K.H., Park S.-H., Park H.-S., Lee H.K.,
RA   Oh T.K., Kim J.F.;
RT   "Genomic blueprint of Hahella chejuensis, a marine microbe producing an
RT   algicidal agent.";
RL   Nucleic Acids Res. 33:7066-7073(2005).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABC31909.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000155; ABC31909.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_041599883.1; NC_007645.1.
DR   AlphaFoldDB; Q2SBR5; -.
DR   SMR; Q2SBR5; -.
DR   STRING; 349521.HCH_05234; -.
DR   EnsemblBacteria; ABC31909; ABC31909; HCH_05234.
DR   KEGG; hch:HCH_05234; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000000238; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..860
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335165"
FT   BINDING         618..625
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   860 AA;  96692 MW;  3137D036C902D908 CRC64;
     MSAIESAIKP QHTPMMQQYL GIKAKHPHQL VFYRMGDFYE LFYEDARRAA ELLDITLTQR
     GQSGGQPIPM AGVPFHAAEG YIGRLVRLGE SVVICEQVGD PAASKGPVER KVVRVVTPGT
     LSDEAFLEEK SDNLLLAISA YKDLFGLATL DIAGGRFLIQ EVRGVEALAS ELQRLRPAEI
     LVSEQFPFLT LLENYTGVQK QPPWYFEQET AQRLLCQQFR TKDLAGFDCE GMSAAIEAAG
     CLFQYAQETQ RSQLPHIRTM IRERREDSII LDAASRRNLE IDVNLAGDYR HTLAWVMDKS
     ATAMGSRMLR RWLNRPLRSQ EEVRQRQNAI KELLEDYQFE ALHETLKQIG DSERILSRVA
     LRSARPRDLA RLRDTLTLLP DLQKQMEELN DTHLRRLAKQ VSEFPDIADL LSRAIEENPP
     VVIRDGGVLR QGFDEELDEL RSISENAGDY LLEIEKREKE RTQLSSLKVG YNRVHGYFIE
     LSRTQSDQAP ADYIRRQTLK NAERFITPEL KTFEDKALSA KSRALSREKM LYDQILETIV
     EQLAPLQDSA RALSELDVLS NFAERALTLN LVCPDLTDEH MLHIEGGRHP VVEQVSQDPF
     VPNDLNLQDK HRMLIITGPN MGGKSTYMRQ TACIVILAYC GSFVPAAKVV IGPIDRVFTR
     MGSSDDIAGG RSTFMVEMTE TANILHYATR QSLVLMDEVG RGTSTFDGLS LAWACAEHLA
     REIQAFTLFA THYFELTALP KTHANVANVH LTATEHNDSI VFLHTVHEGP ASKSYGIQVA
     QLAGVPPQVI NQAQKQLKQL ESGASKPALT APAPSLQDDL FARVEPSEVE TRLQKLDVDS
     LSPREALNML YELKTMSENS