ID   MUTS_HALHL              Reviewed;         868 AA.
AC   A1WXK9;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Hhal_1657;
OS   Halorhodospira halophila (strain DSM 244 / SL1) (Ectothiorhodospira
OS   halophila (strain DSM 244 / SL1)).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Chromatiales;
OC   Ectothiorhodospiraceae; Halorhodospira.
OX   NCBI_TaxID=349124;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 244 / SL1;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Saunders E., Brettin T., Bruce D., Han C., Tapia R., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Hoff W.,
RA   Richardson P.;
RT   "Complete sequence of Halorhodospira halophila SL1.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000544; ABM62421.1; -; Genomic_DNA.
DR   RefSeq; WP_011814443.1; NC_008789.1.
DR   AlphaFoldDB; A1WXK9; -.
DR   SMR; A1WXK9; -.
DR   STRING; 349124.Hhal_1657; -.
DR   EnsemblBacteria; ABM62421; ABM62421; Hhal_1657.
DR   KEGG; hha:Hhal_1657; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000000647; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..868
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335166"
FT   REGION          803..852
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        820..835
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         621..628
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   868 AA;  94681 MW;  BF25854B792D16E8 CRC64;
     MAATQEAETA TNGAGHTPMM RQFLRIKAEY PETLLFYRMG DFYELFYEDA ERAAKLLDIT
     LTTRGESAGA PIPMAGVPVQ SVESYLARLV RLGESVAICE QIGDPNTTKG PVERQVVRVV
     TPGTLTEDAL LEERSANLLT AVAPGPKGRF GVASLELSSG RFSVLEAPDQ EALTAELERL
     RPAELILPDD DQTPAPEGGC VAQRRPSWHF EYDSARRLLL RQLGTHDLSG FGAEELHAPV
     TAAGALLQYL NETQRAALPH VGALTVESRD EAITIDAASR RNLEIEHNLS GGTEHTLASV
     IDTSVTAMGG RLLRRWLQRP LRRRETIAAR HAAVAALADG AFADVRSTLE GCADVERILA
     RVALGTARPR DLTGLRDALE RLPQLQILLG QLNSHRLQAL GVELDEHPQT VDLLQRAIID
     TPPATVRDGG VIADGFDGEL DELRSMSRNA DDYLAALEAE ERAATGIPTL KVGFNRVHGY
     YIEVSRSQSG HMPERYTRRQ TLKAAERFIT PELKRFEEQV LSARERALAR EKALYEQLVA
     DLASELTPLQ RSASALAELD ALAAFAERAR SLDYVQPELA DTPGVRIEGG RHPVVEQALD
     APFVPNDVRL DNRRRMLLIT GPNMGGKSTY MRQTALIALL AYAGAFVPAQ RAVLGPIDRI
     FTRIGAADDL ASGRSTFMVE MTETANILHN ATAESLVLMD EIGRGTSTFD GLALAWATAE
     RLATRIRAFT LFATHYFEMT ALEQIHPGVV NVHLEAAEHG ERIVFLHAVR DGPANQSYGL
     QVAALAGVPQ EVLKAAREKL RSLESGDGGD TGSAQLPLFG PEPVFPPPAQ PEPEPDPIRE
     AVENLDPDGL TPRDALETIY WLKAQCKE