ID   MUTS_HALOH              Reviewed;         896 AA.
AC   B8CX98;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Hore_11670;
OS   Halothermothrix orenii (strain H 168 / OCM 544 / DSM 9562).
OC   Bacteria; Firmicutes; Clostridia; Halanaerobiales; Halanaerobiaceae;
OC   Halothermothrix.
OX   NCBI_TaxID=373903;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H 168 / OCM 544 / DSM 9562;
RX   PubMed=19145256; DOI=10.1371/journal.pone.0004192;
RA   Mavromatis K., Ivanova N., Anderson I., Lykidis A., Hooper S.D., Sun H.,
RA   Kunin V., Lapidus A., Hugenholtz P., Patel B., Kyrpides N.C.;
RT   "Genome analysis of the anaerobic thermohalophilic bacterium
RT   Halothermothrix orenii.";
RL   PLoS ONE 4:E4192-E4192(2009).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP001098; ACL69917.1; -; Genomic_DNA.
DR   RefSeq; WP_012636102.1; NC_011899.1.
DR   AlphaFoldDB; B8CX98; -.
DR   SMR; B8CX98; -.
DR   STRING; 373903.Hore_11670; -.
DR   EnsemblBacteria; ACL69917; ACL69917; Hore_11670.
DR   KEGG; hor:Hore_11670; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_9; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000000719; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..896
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000118685"
FT   REGION          805..826
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         618..625
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   896 AA;  101976 MW;  141633A723DB33B2 CRC64;
     MSKLTPMMQQ YQSIKNKYKD AILFFRLGDF YEMFNDDAKI AARELDLALT ARNKGGGEKA
     PMAGVPCHSA ESYIAKLLEK GYKVAICEQI EDPSEAKGLV SREVVRIITP GTIIENEMLK
     DKENNYLASA ICYKDHLGFS YVDISTGEFY VTQFSQKFSD KVWDELDRIQ PREVIICKEL
     EETENFADKK KQMNFVYNYS RIEKVKAAYN FLLEHFKTNS LSGFGCEDKP AAILAAGEII
     NFLKDTQKRT LEHINRITTY NLTDYMVLDS ATRYNLELTS TIRGNKHKGS LLNVLDQTIT
     SMGGRLIKKW INQPLIDRNK IETRLDAVEE LVNNYLLLQE IREHLKGIYD LERILGKVSY
     GSANARDLAA LKYSILKLPQ IKKDLEQLNT KLFKNMHETF DPLIDLAGLL DRSIVDEPPV
     SVREGGLIKD GYSSELDELR KARTEGKDWI ANLQKTERER TGISSLKVGF NKVFGYYIEI
     TKANLDRVPD NYTRKQTLSN SERFITPELK EKEALVLGAE EKINDLEYKL FVKIRDIVRD
     NIKRIKKTAA IISKLDVLTS LAQNALERDY NRPRINNDGV IEIIKGRHPV VEDMGKGAFV
     PNDTYLDLEE ERFIIITGPN MSGKSTYMRQ VALIVLMAQM GSFVPADKAT IGIVDRIFTR
     VGASDDLTTG QSTFMVEMNE VANIVNNATR NSLIILDEVG RGTSTYDGLS IAWAVSEYIN
     NPDRIGARTL FATHYHELTQ LENRPGIKNY NVLVEEDEDG VHFLHKIIPG KASESYGIEV
     AQLAGLPMEI IIRAQEILAE LEKKGKESTK TGKGENKNIS HKTESDLINN IHESDKEYLT
     KRNTNDKVQQ LPLFKSEYRV IEKIKNKDIV NMTPMEAINF LFEIQKELKE KGENYA