ID   MUTS_HALWD              Reviewed;         932 AA.
AC   Q18FJ9;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=HQ_3158A;
OS   Haloquadratum walsbyi (strain DSM 16790 / HBSQ001).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC   Haloferacaceae; Haloquadratum.
OX   NCBI_TaxID=362976;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 16790 / HBSQ001;
RX   PubMed=16820047; DOI=10.1186/1471-2164-7-169;
RA   Bolhuis H., Palm P., Wende A., Falb M., Rampp M., Rodriguez-Valera F.,
RA   Pfeiffer F., Oesterhelt D.;
RT   "The genome of the square archaeon Haloquadratum walsbyi: life at the
RT   limits of water activity.";
RL   BMC Genomics 7:169-169(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AM180088; CAJ53258.1; -; Genomic_DNA.
DR   RefSeq; WP_011572364.1; NC_008212.1.
DR   AlphaFoldDB; Q18FJ9; -.
DR   SMR; Q18FJ9; -.
DR   STRING; 362976.HQ_3158A; -.
DR   EnsemblBacteria; CAJ53258; CAJ53258; HQ_3158A.
DR   GeneID; 4194318; -.
DR   KEGG; hwa:HQ_3158A; -.
DR   eggNOG; arCOG02897; Archaea.
DR   HOGENOM; CLU_002472_3_2_2; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000001975; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..932
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335244"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          865..892
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        867..881
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         648..655
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   932 AA;  102439 MW;  B84837F51D2F7522 CRC64;
     MTTDTDTDVD AGTDLEPQPE GPPEKMLTRR TELTPMLSQY LDCCEAHPDA LVLFQVGDFY
     EAFCEAATTV AQVCEVTLTQ REDSTGTYRM AGVPIDNATS YIEALLSADF RVAIAEQVEE
     AEATSGLVDR AVTNIITPGT VTNGDLLTDA AATYLGAVSI TDSDGDASEM TGAIATVDVS
     TGACRVTSVE HDQIYEELSR LRPAELLIGP EVDTKTIESS SLPFETMQTT HNSGAFELAT
     ATQTLEAYVD EPTAFLSSAE RRAVGAVLDY AEYTQGDCGP LEYVSRIRRY KTDTALRVDA
     TAIQSLELFD SRQPYGETLI ETIDETSSAL GRRTLESWLR RPLADHEAIK TRYDAVAALA
     ENPLVVETLT EKLSHIYDLE RLTARTAREQ ADARDMRSLL QSLDSIPEIK SALIEVLTET
     ELPAETLEQL QAELDSLDDI RTLIDTAVCS DPPQTVTDGD VIAKGFNDDL DDIREREEAG
     REWVSELETR ERERTGIDSL EVGYTEVHGY YIEVTNPNLD HVPDEYTRRQ TLKNAERFYT
     PALKRREDEI IAASNRADKL EYELFCDIRA EVAAETSRLQ AVADAIGRLD ALVSFATIAI
     SHAYVRPEIT ADTLAIEAGR HPVVEQTQAE FVPNGITFEK GHIAMITGPN MSGKSTYMRQ
     IAHICILAQA GSFVPADAAQ IPVLDRIFTR IGASDDISGG ESTFMREMSE MTDILHNATE
     SSLILLDEVG RGTSTTDGRA IARATVEFIH NEIGARTLFT THYHDLTTVT GSLPSAFNLH
     FKVHRKTHPD NDASVTFLHR VTSGAADSSY GVEVAKLAGV PTPVVEQAQR YIHTEGEDYT
     EISEQGTHHH DELTHAEMVS VDHDNQQNQA SDDDEIARSP RGADTNTDAG INQSDVSANI
     DVLKSLRDID IARMTPLEAL NMLENLQRRL DE