ID   MUTS_HAMD5              Reviewed;         854 AA.
AC   C4K6P7;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   07-JUL-2009, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=HDEF_1628;
OS   Hamiltonella defensa subsp. Acyrthosiphon pisum (strain 5AT).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; aphid secondary symbionts; Candidatus Hamiltonella.
OX   NCBI_TaxID=572265;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=5AT;
RX   PubMed=19451630; DOI=10.1073/pnas.0900194106;
RA   Degnan P.H., Yu Y., Sisneros N., Wing R.A., Moran N.A.;
RT   "Hamiltonella defensa, genome evolution of protective bacterial
RT   endosymbiont from pathogenic ancestors.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:9063-9068(2009).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP001277; ACQ68240.1; -; Genomic_DNA.
DR   RefSeq; WP_015874007.1; NC_012751.1.
DR   AlphaFoldDB; C4K6P7; -.
DR   SMR; C4K6P7; -.
DR   STRING; 572265.HDEF_1628; -.
DR   EnsemblBacteria; ACQ68240; ACQ68240; HDEF_1628.
DR   GeneID; 66261236; -.
DR   KEGG; hde:HDEF_1628; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000002334; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..854
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000202739"
FT   BINDING         614..621
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   854 AA;  96150 MW;  9ADE36FD06B0E7FA CRC64;
     MDSINKCESH TPMMQQYLRL KSEHPEVFLF YRMGDFYELF YDDAKRASRL LDISLTQRGQ
     SAGTPIPMAG VPYHVIDNYL AKLVQLGESA AICEQVGDPS TSKGPVERKV VRIVTPGTIS
     DEALLQEKQD NLLAAVWQDK QGLGYATLDI SSGRFRAMEP KDLEALKTEL QRTHPSELLY
     PETFELIDLI ESRQGLRRRP LWEFELETAR QQLNLQFGTQ DLTGFGVEQA HLALRAAGCL
     LQYVKDTQRT SLPHIRELIL QHEEDNVTID AASRRNLELT ENLSGGTENT LASILDCTVT
     SMGSRMLKRW LHMPITDMST LHHRQEAIRV LQHVASDLKP LLRKVGDLER ILARLALRTA
     RPRDLARMRL AFEQLPEIHD VLNTCKSQHL KKLLSEIGQF DALLDLLRRA IVDVPPVLIR
     DGGVIATGYN EELDKWRALS DGAHDYLNEL EIRERHELKL DTLKVGFNAI HGYYIQVSRA
     QSHLIPAHYA RRQTLKNVER YIIPELKEYE DKVLTSKGKA LSIEKDLYEE IFDLLLPHIA
     SLQTSSTALA ELDVLSNLAE RADTLNYVCP VLTEKSVIEI TGGRHPVVEQ VSKQPFIANP
     ISLSPERRML IITGPNMGGK STYMRQTALI VLLAHIGSFV PADKAIIGSV DRIFTRIGAA
     DDLASGRSTF MVEMTETANI LHNATEKSLV LMDEIGRGTS TYDGLSLAWA CAENLSIHIK
     SMTLFATHYF ELTSLPEKIN GIVNVHLQAL EQGDEIAFMH SVHEGAASKS YGLAVAALAG
     VPKKVIDRAR QRLEELEFTL EENGHTKPSL PASKPVFEKE STDHPVIRKL KTLKPDTMTP
     YDALQWIYYL QKMF