ID   MUTS_HERAR              Reviewed;         893 AA.
AC   A4G717;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-JAN-2009, sequence version 3.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=HEAR2167;
OS   Herminiimonas arsenicoxydans.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Oxalobacteraceae; Herminiimonas.
OX   NCBI_TaxID=204773;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ULPAs1;
RX   PubMed=17432936; DOI=10.1371/journal.pgen.0030053;
RA   Muller D., Medigue C., Koechler S., Barbe V., Barakat M., Talla E.,
RA   Bonnefoy V., Krin E., Arsene-Ploetze F., Carapito C., Chandler M.,
RA   Cournoyer B., Cruveiller S., Dossat C., Duval S., Heymann M., Leize E.,
RA   Lieutaud A., Lievremont D., Makita Y., Mangenot S., Nitschke W., Ortet P.,
RA   Perdrial N., Schoepp B., Siguier P., Simeonova D.D., Rouy Z., Segurens B.,
RA   Turlin E., Vallenet D., van Dorsselaer A., Weiss S., Weissenbach J.,
RA   Lett M.-C., Danchin A., Bertin P.N.;
RT   "A tale of two oxidation states: bacterial colonization of arsenic-rich
RT   environments.";
RL   PLoS Genet. 3:518-530(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CU207211; CAL62304.2; -; Genomic_DNA.
DR   AlphaFoldDB; A4G717; -.
DR   SMR; A4G717; -.
DR   STRING; 204773.HEAR2167; -.
DR   EnsemblBacteria; CAL62304; CAL62304; HEAR2167.
DR   KEGG; har:HEAR2167; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_1_4; -.
DR   Proteomes; UP000006697; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..893
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335167"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         641..648
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   893 AA;  97700 MW;  DEFD9DEA23E5E77F CRC64;
     MESTMSSAST NASPPSASEK HTPMMQQYLR IKAEHPETLL FYRMGDFYEV FFEDAEKASR
     LLGITLTQRG SSNGNPIKMA GVPFHAVDQY LSKLVKLGES IALCEQIGDP ATSKGPVERK
     VLRVITPGTL SDSDLLPEKS EQPLLALYST TQRKTITIGL AWLSMASGAL KLMEFTTDAR
     NAATRLKHEL ERIAPAEVLL PGSIDGPDSD YAFAKNTTVP DWHFDIAHGS KALHEQLKVS
     TLTGFGAEHL NAAIGAAGAL LRYAQATQGK GLQHVRALTV ETENEFIGLD AATRRNLELT
     ETIRGQDNNS ATLFSLLDHC RTAMGSRLLR HWLHHARRDQ AVARARHAAI NALMRTDACT
     GLASTLASVP DVERIATRIA LQSARPRDLA GMRGGLQQLP SLRAYVSMCN QDADAPLLKT
     IHDALATPSE CLDLVERAIA LEPAAMVRDG GVIARGFDAE LDELRGLSEN AGQFLVDLET
     RERTRTGINN LRVEYNKVHG FYIEVTHGQT DKVPDDYRRR QTLKNAERYI TPELKAFEDK
     ALSAQERALA REKYLYDQVL QQMAQHIGTL QNIAHALAQL DTLVALAEHA LRHNWCAPQL
     IAEPTIAIEQ GRHPVVENHI ERFIANDCLL NNESRLLLIT GPNMGGKSTY MRQVALITLL
     AYVGSFVPAT SATIGPIDRI FTRIGAADDL AGGRSTFMVE MTESAAILNG ATENSLVLMD
     EVGRGTSTFD GLALAWAIAR HLIDSTRSFT LFATHYFELT QLPEVHPSAA NVHLSAVEHK
     DSIVFLHAVQ AGPASQSYGL QVAQLAGVPQ AVIRAARKHL ATLEANSMQA TPQFDLFADP
     DHLIPTSDVE TAMAQPSALD EALADINPDA LSPRDALDAL YRLKELSNQH REK