ID   MUTS_HISS2              Reviewed;         859 AA.
AC   B0UWV7;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=HSM_1896;
OS   Histophilus somni (strain 2336) (Haemophilus somnus).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Histophilus.
OX   NCBI_TaxID=228400;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2336;
RG   US DOE Joint Genome Institute;
RA   Siddaramappa S., Duncan A.J., Challacombe J.F., Rainey D., Gillaspy A.F.,
RA   Carson M., Gipson J., Gipson M., Bruce D., Detter J.C., Han C.S., Land M.,
RA   Tapia R., Thompson L.S., Orvis J., Zaitshik J., Barnes G., Brettin T.S.,
RA   Dyer D.W., Inzana T.J.;
RT   "Complete sequence of Haemophilus somnus 2336.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000947; ACA31684.1; -; Genomic_DNA.
DR   AlphaFoldDB; B0UWV7; -.
DR   SMR; B0UWV7; -.
DR   STRING; 228400.HSM_1896; -.
DR   PRIDE; B0UWV7; -.
DR   EnsemblBacteria; ACA31684; ACA31684; HSM_1896.
DR   KEGG; hsm:HSM_1896; -.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..859
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335164"
FT   BINDING         614..621
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   859 AA;  96389 MW;  2FC024CC5187AADF CRC64;
     MKAMHTFENH TPMMKQYLKI KAENPDVLLF YRMGDFYELF YDDAKKAAEL LDISLTKRGQ
     SAGQPVPMAG VPYHAIEGYL AKLVQLGESV AICEQVGEPV IAKGPVERQV VRIVTPGTVS
     DEALLPEKQD NLIATIYQEK TQFGLAVLDM TSGCFQISEL QDAASLQAEL QRIQPVELLY
     SEALEDKHLI EQFKGLRRRP LWEFELSTAI QLLNRQFGTK DLRGFGVEKA VLGLCAAGCL
     LQYAKETQRT ALPHIQSISL LQNSDTVQID ASTRRNLELT QNLAGGTENT LAAILDKCVT
     PMGSRLLKRW IHQPIRNIEK LQYRQQHIQM LLQQNLVEEL QPLLRQVGDM ERILARVALR
     SARPRDLTRL RTALEQIPFI QHQLTKIPHF VAFSQQIADF SVQLALLQRA IIDNPPLLIR
     DGGVIAEGYN EELDEWRSLS EGATRYLKDL EQRERANTGI DTLKIGFNAV HGYYIQISQG
     QAHKAPLHYV RRQTLKNVER YIIPELKTYE EKVLKAKGAS LALEKQLYDE IFDQLLPHLG
     DLQLASLTLA ELDVLTNLAE RAETLNYVQP QFSTQVGLQI MQGRHPVVEQ VLKEPFIANP
     VELNQKRHLL IITGPNMGGK STYMRQTALI TLMAYIGSFV PAESAVIGPI DRIFTRIGAS
     DDLASGRSTF MVEMTEMANI LHQATEQSLV LIDEIGRGTS TYDGLSLAWA CAEQLAQKIR
     SLTLFATHYF ELTGLPEKIE GIHNVHLDAF EHNDSIAFMH SVQEGAASKS YGLAVAALAG
     VPQNVIKSAK QKLKQLETLS QQNSYQSQSV LTQVQGELTL MEEEENTSAV IETLKTLDPN
     ELSPKQALEC LYQLKKMLN