ID   MUTS_HYDCU              Reviewed;         871 AA.
AC   Q31F87;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Tcr_1594;
OS   Hydrogenovibrio crunogenus (strain DSM 25203 / XCL-2) (Thiomicrospira
OS   crunogena).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Thiotrichales;
OC   Piscirickettsiaceae; Hydrogenovibrio.
OX   NCBI_TaxID=317025;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 25203 / XCL-2;
RX   PubMed=17105352; DOI=10.1371/journal.pbio.0040383;
RA   Scott K.M., Sievert S.M., Abril F.N., Ball L.A., Barrett C.J., Blake R.A.,
RA   Boller A.J., Chain P.S.G., Clark J.A., Davis C.R., Detter C., Do K.F.,
RA   Dobrinski K.P., Faza B.I., Fitzpatrick K.A., Freyermuth S.K., Harmer T.L.,
RA   Hauser L.J., Huegler M., Kerfeld C.A., Klotz M.G., Kong W.W., Land M.,
RA   Lapidus A., Larimer F.W., Longo D.L., Lucas S., Malfatti S.A., Massey S.E.,
RA   Martin D.D., McCuddin Z., Meyer F., Moore J.L., Ocampo L.H. Jr., Paul J.H.,
RA   Paulsen I.T., Reep D.K., Ren Q., Ross R.L., Sato P.Y., Thomas P.,
RA   Tinkham L.E., Zeruth G.T.;
RT   "The genome of deep-sea vent chemolithoautotroph Thiomicrospira crunogena
RT   XCL-2.";
RL   PLoS Biol. 4:1-17(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000109; ABB42186.1; -; Genomic_DNA.
DR   RefSeq; WP_011371015.1; NC_007520.2.
DR   AlphaFoldDB; Q31F87; -.
DR   SMR; Q31F87; -.
DR   STRING; 317025.Tcr_1594; -.
DR   PRIDE; Q31F87; -.
DR   EnsemblBacteria; ABB42186; ABB42186; Tcr_1594.
DR   KEGG; tcx:Tcr_1594; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..871
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335239"
FT   BINDING         617..624
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   871 AA;  96951 MW;  1D558B8B59FD15E1 CRC64;
     MADTIKHTPM MQQYLAVKAD YPNQLLFYRM GDFYELFYED AVKASELLEI TLTARGKSGG
     NPIPMAGIPH HSAEGYLAKL VKLGQSVAIC EQIGDPSISK GPVERKVVRV ITPGTLVEDA
     LLEDKSENLL AAIFQQADEY GLATLDVASG RFEATLLPDS TQLSAEVERL KPAEIILPDD
     PLFKQNLPES IQNRPGLVDY PSWHFEKDSC RKRLIDHFGT QDLVAFGCDQ LPAVISAAGV
     ILHYAQSMLQ NTLAHVFSLQ TYQADDALAL DAMSRRNLEL DTNLTGGKNH TLFAILDNAT
     TAMGSRLMNR WLNQPLRNRD IINDRFNAIE DIIEQHSQEE FRSALKPIGD LERILSRVSL
     YSARPRDILH LGRSLNQLPE LQALLKQQTA NKWQQLSKQL GLYPELASQL ETALVESPPM
     LMRDGGVFAE GYDSELDELR NLKNQAGDYL LALEAREKER TGITTLKVGY NRVHGYYIEV
     SKLQSDNVPA DYVRRQTLKA QERYITPELK EFEDKVLSAN EKALAREKWL YQQLLERLNQ
     DLQALQRTAA ALAETDVLVS LARQAINLNL TRPTLSSEPG IDIKQGRHLT VEALSNQPFI
     PNDTCFDEQR RLQIITGPNM GGKSTFMRQT ALIAIMAYMG SFVPAESATL GPIDRIFTRI
     GASDDLTSGR STFMVEMTET ANILHHASPE SLILMDEVGR GTSTFDGLAL AWAIAEQMAQ
     SIQGYCLFAT HYFELTTLVE QFNNTVNIHL SAIEHQDKIV FMHQVEEGPA SQSYGLQVAA
     LAGVPTAVID KAKKHLHRLE NQTAAQQQTS GTASSAKESV QQFDLFAQPA LPEAIETMLT
     DLKALSVDDL TPRQALEKLY EVTNTVKNAS E