ID   MUTS_HYPNA              Reviewed;         890 AA.
AC   Q0C5G6;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=HNE_0297;
OS   Hyphomonas neptunium (strain ATCC 15444).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomonadales;
OC   Hyphomonadaceae; Hyphomonas.
OX   NCBI_TaxID=228405;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15444;
RX   PubMed=16980487; DOI=10.1128/jb.00111-06;
RA   Badger J.H., Hoover T.R., Brun Y.V., Weiner R.M., Laub M.T., Alexandre G.,
RA   Mrazek J., Ren Q., Paulsen I.T., Nelson K.E., Khouri H.M., Radune D.,
RA   Sosa J., Dodson R.J., Sullivan S.A., Rosovitz M.J., Madupu R.,
RA   Brinkac L.M., Durkin A.S., Daugherty S.C., Kothari S.P., Giglio M.G.,
RA   Zhou L., Haft D.H., Selengut J.D., Davidsen T.M., Yang Q., Zafar N.,
RA   Ward N.L.;
RT   "Comparative genomic evidence for a close relationship between the
RT   dimorphic prosthecate bacteria Hyphomonas neptunium and Caulobacter
RT   crescentus.";
RL   J. Bacteriol. 188:6841-6850(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000158; ABI76304.1; -; Genomic_DNA.
DR   RefSeq; WP_011645327.1; NC_008358.1.
DR   AlphaFoldDB; Q0C5G6; -.
DR   SMR; Q0C5G6; -.
DR   STRING; 228405.HNE_0297; -.
DR   EnsemblBacteria; ABI76304; ABI76304; HNE_0297.
DR   KEGG; hne:HNE_0297; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_5; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001959; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..890
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335168"
FT   BINDING         646..653
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   890 AA;  94096 MW;  C570D2FFA5BDBB13 CRC64;
     MPDTARPSAT TEPTPFMAQY LSIKAEHPGA LLFFRMGDFY ELFFQDAVEA ASILDITLTS
     RGEHDGKPIP MAGVPYHAAE GYLARLIKGG CRVAVCEQME TPAEAKKRGS KSIVQRGVVR
     IVTPGTLTED ALLPARQGQA LAAIAFSGAG EAALAVCDVS TGAFDLTAIP AARLGEALLA
     WPLSELVISA DDADRPLILE ARGFLSAPIT ERPGRAATAK SGEALLKEVF GLAALDSLGD
     FSRVEFAAAG LLLDYVKLTQ AGAPIRLRAP RRPDTGGILL IDPATRASLE IDRSISGGRD
     GTLLAVIDRT VTAPGARLLA ARLARPSRSV SEITSRYDAV SHLLGDAGQL EDVRVRLKSA
     PDLERAVMRL NLGRGGPRDM AALSKAVLSG AEAAGVLGRG LPPRLAEVAE TLGLSGAPSV
     RAFAEDLARA LTEAPPMLAR DGGFIAQGWD VALDEVRALR DGSRRVIAEL QAKYADQTGI
     NALKVKFNNV LGYFIEVPAA KADPMLRAPL SADFIHRQTM AGAVRFSTHE LADLAGRIGR
     AEDEAKAREI AIFEAFCAKV EELTGPLAVI AAALAELDVA ASHAVWAAET GAVRPALDPR
     PVFEAKGLRH PVVEAALRKE GKGFTANDLH LDAEGNEGAR FLLVTGPNMA GKSTYLRQSA
     LAVILAQAGA FVPAASLRLG LSDRVFSRVG ASDDLARGRS TFMVEMVETA AILNQATPES
     FVILDEVGRG TATWDGLAIA WAAAEHLHDT NRCRAIFATH YHELTDLAAR MPAASNASLK
     AREWKQDLIF LHEVQPGPAD RSYGVQVAKL AGLPRAAVAR AGQILKKLEA GPSASENLPL
     FAMVAEDPAP EFSPESSAVI EALAAADPDS LTPREALDLV YRLKDLSRGA