ID   MUTS_IDILO              Reviewed;         871 AA.
AC   Q5QUB6;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 2.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=IL0744;
OS   Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Idiomarinaceae; Idiomarina.
OX   NCBI_TaxID=283942;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-735 / DSM 15497 / L2-TR;
RX   PubMed=15596722; DOI=10.1073/pnas.0407638102;
RA   Hou S., Saw J.H., Lee K.S., Freitas T.A., Belisle C., Kawarabayasi Y.,
RA   Donachie S.P., Pikina A., Galperin M.Y., Koonin E.V., Makarova K.S.,
RA   Omelchenko M.V., Sorokin A., Wolf Y.I., Li Q.X., Keum Y.S., Campbell S.,
RA   Denery J., Aizawa S., Shibata S., Malahoff A., Alam M.;
RT   "Genome sequence of the deep-sea gamma-proteobacterium Idiomarina
RT   loihiensis reveals amino acid fermentation as a source of carbon and
RT   energy.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:18036-18041(2004).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAV81585.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE017340; AAV81585.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_041291755.1; NC_006512.1.
DR   AlphaFoldDB; Q5QUB6; -.
DR   SMR; Q5QUB6; -.
DR   STRING; 283942.IL0744; -.
DR   EnsemblBacteria; AAV81585; AAV81585; IL0744.
DR   KEGG; ilo:IL0744; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_1_6; -.
DR   Proteomes; UP000001171; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..871
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224376"
FT   REGION          806..837
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         620..627
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   871 AA;  97870 MW;  E6B351C01CB0223A CRC64;
     MPEFSDKQIQ SHTPMMQQYL RIKAEHADML LFYRMGDFYE LFFEDAKRSA QLLDISLTAR
     GQSNGEPIPM AGVPYHAVEN YLARLVNMGE SVAICEQIGD PATSKGPVER KVVRIVTPGT
     VTDESLLAEK RQNLLVAICP LNPKQPEAEY AISSLELSSG RFWLTKAHSS EQLAAEMQRL
     EPAELLYPES ISLAGLPLAK AKCKRRPAWE FEQQTAFMLL TRQFGTQHLE GFGIKNNEPT
     LAAAGAILHY VKETQRAALP HIQALITEHP QDAIILDAAT RRNLELQQSM GEGDTHLSAV
     LDKTVSAMGS RQFQRWLQRP IRNHQELNQR YDAVDALKEN LNFENIQLTL KQLADIERIV
     ARVGLRSARP KDFARLRDSL AKIPEVRASL SHRSLSYLHD IIEPFPEVVD LLTKAVIEQP
     PLLIRDGGVI AEGYDKELDE LRDLATGATD YLKQLEQRER ERSGIATLKV GYNRVHGYFI
     EVSRQSSEAV PDDYQRRQTL KNTERYIIPE LKEHEDKVLN AQARSLAREK WLYDQLFEHL
     LPQVTALQKS ASGLAQLDTL CCFARLADNY RYCRPQLQKE TSLIELEAAR HPVIEQLSDE
     PFIANPMSLT PQQRMLMITG PNMGGKSTYM RQAALIVILA HMGCYVPADK AIIGDIDRIF
     TRIGASDDLA SGRSTFMVEM TETANILHNA TAKSLVLMDE IGRGTSTYDG LSLAWSCADY
     LSRQLQCLTL FATHYFELTE LAEELPATVN VHVDAKEHGD TIAFLHKVSP GAASQSFGLQ
     VAKLAGVPEH VIHKAKQKLS ELEHTHHGGL NEPKQATMEL TPPPEAIPSH TEKRNPLLDE
     LEQLDINDLT PKQALDILYQ WQQKQKGSTQ S