ID   MUTS_JANMA              Reviewed;         882 AA.
AC   A6SXI2;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=mma_1289;
OS   Janthinobacterium sp. (strain Marseille) (Minibacterium massiliensis).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Oxalobacteraceae; Janthinobacterium.
OX   NCBI_TaxID=375286;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Marseille;
RX   PubMed=17722982; DOI=10.1371/journal.pgen.0030138;
RA   Audic S., Robert C., Campagna B., Parinello H., Claverie J.-M., Raoult D.,
RA   Drancourt M.;
RT   "Genome analysis of Minibacterium massiliensis highlights the convergent
RT   evolution of water-living bacteria.";
RL   PLoS Genet. 3:1454-1463(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000269; ABR88339.1; -; Genomic_DNA.
DR   RefSeq; WP_012079146.1; NC_009659.1.
DR   AlphaFoldDB; A6SXI2; -.
DR   SMR; A6SXI2; -.
DR   STRING; 375286.mma_1289; -.
DR   PRIDE; A6SXI2; -.
DR   EnsemblBacteria; ABR88339; ABR88339; mma_1289.
DR   KEGG; mms:mma_1289; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_4; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   BioCyc; JSP375286:MMA_RS06700-MON; -.
DR   Proteomes; UP000006388; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..882
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335170"
FT   BINDING         635..642
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   882 AA;  96321 MW;  555E49FDDA9D1ABE CRC64;
     MKTIKPQTPE GNEKHTPMMQ QYLRIKAEYP TTLVFYRMGD FYELFFDDAE KASRLLGITL
     TQRGASNGNP IKMAGVPFHA VDQYLSKLVK LGESIAICEQ IGDPATSKGP VERKVLRVIT
     PGTLTDSDLL PEKSEQPLLA LYSTTQRKTA TIGLAWLSMA SGVLKLMEFA TDAQNADVRL
     KHELERIAPA EILLPGSVND LFSEFSLAKN TTVPDWHFDI AHGTKALYEQ LNVGTLTGFG
     AENLSAAIGA AGALLRYAQS TQGKGLQHVR TLTVETENEF IGLDAATRRN LELTETIRGQ
     DANAATLFSL LDHCRTAMGS RLLRHWLHHA RRDQSVAMAR HAAINALMRA DACSGLASTL
     ASVPDVERIT TRIALLSARP RDLAGMRGGL QQLPSLRAYV SMCNKDADAP LLKTIHDALA
     TPSDCLDLVE RAIAMEPAAM VRDGGVIARG FDAELDELRG LSENAGQFLI DLETRERART
     GINNLRVEYN KVHGFYIEVT HGQTDKVPDD YRRRQTLKNA ERYITPELKA FEDKALSAQE
     RALAREKYLY EQVLQQMTQH IATLQNIAHA LAQLDTLVAL AEHALRHNWC APQLVSEPTI
     TIEQGRHPVV ENHIERFIAN DCLLSSECKL LLITGPNMGG KSTYMRQVAL ITLLAYVGSF
     VPASSAVIGP IDRIFTRIGA ADDLAGGRST FMVEMTESAA ILNGATENSL VLMDEVGRGT
     STFDGLALAW AIAKHLIDNT KSFTLFATHY FELTQLPEIH PTAANVHLSA VEHKDSIVFL
     HAVQAGPASQ SYGLQVAQLA GVPQPVIRAA RKHLALLEAN SMQATPQFDL FAGGGSPTTV
     ESAAEPQQAS AVDEAIAAIN PDALSPREAL DALYRLKELS NQ