ID   MUTS_JANSC              Reviewed;         877 AA.
AC   Q28VY6;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Jann_0209;
OS   Jannaschia sp. (strain CCS1).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Roseobacteraceae; Jannaschia; unclassified Jannaschia.
OX   NCBI_TaxID=290400;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CCS1;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D.,
RA   Han C., Tapia R., Gilna P., Chertkov O., Saunders E., Schmutz J.,
RA   Larimer F., Land M., Kyrpides N., Lykidis A., Moran M.A., Belas R., Ye W.,
RA   Buchan A., Gonzalez J.M., Schell M.A., Richardson P.;
RT   "Complete sequence of chromosome of Jannaschia sp. CCS1.";
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000264; ABD53126.1; -; Genomic_DNA.
DR   RefSeq; WP_011453335.1; NC_007802.1.
DR   AlphaFoldDB; Q28VY6; -.
DR   SMR; Q28VY6; -.
DR   STRING; 290400.Jann_0209; -.
DR   EnsemblBacteria; ABD53126; ABD53126; Jann_0209.
DR   KEGG; jan:Jann_0209; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_5; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000008326; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..877
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335169"
FT   BINDING         630..637
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   877 AA;  95179 MW;  FE6EB242D34F7B7A CRC64;
     MNAQVTPMMA QYLEIKAAHP DALLFYRMGD FYEMFFDDAV AAAEALDIAL TKRGKHNGED
     IAMCGVPAHS AESYLLTLIR KGFRVGICEQ MEDPATAKKR GGSKAVVRRE VVRLVTPGTL
     TEDTLLEARR HNYLASYADV RGEGALAWCD ISTGDFRVMR CPAVRLGPEL ARLSPKEVLV
     SDGLDIARQD AIIELGAAVT PLSPGSFDSA SAEQRLAGLF SVSTLEGFGN FARAEVSAMG
     ALIDYLELTQ KGALPLLRAP RQQSADRLLQ LDTATRRNLE LTQALSGGRA NSLLSVLDRT
     QTAGGARLLQ RRLTGPSTDL DVIRARHESV SFFFSDTLIR DDLEAELRRI PDLDRALSRL
     ALDRGGPRDL SAIRDGLSGA ARLSDKLKIV DLPPLLEGAV QDLQGHDELS ALLDEALVAE
     PPVQLRDGGL IAPGYHAELD EARTLRDEGR SVIATMQADY VEATGVNALK IKHNNVLGYF
     IETTATHAEK MLNPPLSERF IHRQTTANQV RFTTVELSEL ETKILNAGNR ALEIERVLFQ
     SLRDAILNCQ DQIGQAARGL AELDLSAALA RRAREGDWTQ PEMTEDRAFM IEGARHPVVE
     AALAKDGTSF VANDCDLSAE GGAAITLLTG PNMAGKSTYL RQNALLVIMA QTGSFVPAKC
     AKIGLVSQVF SRVGASDDLA RGRSTFMVEM VETATILNQA DDRALVILDE IGRGTATYDG
     LSIAWATLEH LHETNQCRAL FATHYHEMTS LASKLDGLTN ATVAVKEWEG EVIFLHEVRE
     GAADRSYGVQ VAKLAGLPDA VIARAQVVLD ALEKGEREGG ERKAVIDDLP LFAMMPAPAP
     APSAPSLVEE KLRAVHPDEM TAREALNLLY ELKAELS