ID   MUTS_KLEP7              Reviewed;         853 AA.
AC   A6TD24;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   OrderedLocusNames=KPN78578_30340; ORFNames=KPN_03094;
OS   Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=272620;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700721 / MGH 78578;
RG   The Klebsiella pneumonia Genome Sequencing Project;
RA   McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P.,
RA   Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K.;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000647; ABR78495.1; -; Genomic_DNA.
DR   RefSeq; WP_004151059.1; NC_009648.1.
DR   AlphaFoldDB; A6TD24; -.
DR   SMR; A6TD24; -.
DR   STRING; 272620.KPN_03094; -.
DR   EnsemblBacteria; ABR78495; ABR78495; KPN_03094.
DR   GeneID; 61334429; -.
DR   KEGG; kpn:KPN_03094; -.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000000265; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..853
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000071277"
FT   BINDING         614..621
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   853 AA;  95082 MW;  DF4644F03BC2D78B CRC64;
     MSTIDNLDAH TPMMQQYLKL KAQHPDILLF YRMGDFYELF YDDAKRASQL LDISLTKRGA
     SAGEPIPMAG IPHHAVENYL AKLVNQGESV AICEQIGDPA TTKGPVERKV VRIVTPGTIS
     DEALLQERQD NLLAAIWQDS KGFGYATLDI SSGRFRLSEP ADRETMAAEL QRTNPAELLY
     AEDFAESSLI EGRRGLRRRP LWEFEIDTAR QQLNLQFGTR DLVGFGVENA PRGLCAAGCL
     LQYVKDTQRT SLPHIRSITM ERQQDSIIMD AATRRNLEIT QNLAGGTDNT LASVLDCTVT
     PMGSRMLKRW LHMPVRDTAV LVERQQTIGA LQERYTELQP VLRQVGDLER ILARLALRTA
     RPRDLARMRH ALQQLPLLRE LLADVDSQPV QKLREKMGEF TELRELLERA VIDAPPVLVR
     DGGVIAPGYS EELDEWRALA DGATDYLDKL EIRERERLGL DTLKVGYNAV HGYYIQISRG
     QSHLAPIHYV RRQTLKNAER YIIPELKEYE DKVLTSKGKA LALEKQLYDE LFDLLLPHLA
     DLQTSASALA ELDVLVNLAE RAETLNYCCP TFSDKPGIRI SEGRHPVVEQ VLKEPFIANP
     LQLAPQRRML IITGPNMGGK STYMRQTALI ALLAYIGSYV PAQKVEIGPI DRIFTRVGAA
     DDLASGRSTF MVEMTETANI LHNATEHSLV LMDEIGRGTS TYDGLSLAWA CAENLANKIK
     ALTLFATHYF ELTQLPEKME GVANVHLDAL EHGDTIAFMH SVQDGAASKS YGLAVAALAG
     VPKEVIKRAR QKLRELESIS PNAAATQVDG TQMSLLAAPE ETSPAVEALE NLDPDSLTPR
     QALEWIYRLK SLV