ID   MUTS_KORVE              Reviewed;         882 AA.
AC   Q1IN52;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-JUN-2006, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   OrderedLocusNames=Acid345_2697;
OS   Koribacter versatilis (strain Ellin345).
OC   Bacteria; Acidobacteria; Acidobacteriales; Acidobacteriaceae;
OC   Candidatus Koribacter.
OX   NCBI_TaxID=204669;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ellin345;
RX   PubMed=19201974; DOI=10.1128/aem.02294-08;
RA   Ward N.L., Challacombe J.F., Janssen P.H., Henrissat B., Coutinho P.M.,
RA   Wu M., Xie G., Haft D.H., Sait M., Badger J., Barabote R.D., Bradley B.,
RA   Brettin T.S., Brinkac L.M., Bruce D., Creasy T., Daugherty S.C.,
RA   Davidsen T.M., DeBoy R.T., Detter J.C., Dodson R.J., Durkin A.S.,
RA   Ganapathy A., Gwinn-Giglio M., Han C.S., Khouri H., Kiss H., Kothari S.P.,
RA   Madupu R., Nelson K.E., Nelson W.C., Paulsen I., Penn K., Ren Q.,
RA   Rosovitz M.J., Selengut J.D., Shrivastava S., Sullivan S.A., Tapia R.,
RA   Thompson L.S., Watkins K.L., Yang Q., Yu C., Zafar N., Zhou L., Kuske C.R.;
RT   "Three genomes from the phylum Acidobacteria provide insight into the
RT   lifestyles of these microorganisms in soils.";
RL   Appl. Environ. Microbiol. 75:2046-2056(2009).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000360; ABF41698.1; -; Genomic_DNA.
DR   RefSeq; WP_011523499.1; NC_008009.1.
DR   AlphaFoldDB; Q1IN52; -.
DR   SMR; Q1IN52; -.
DR   STRING; 204669.Acid345_2697; -.
DR   EnsemblBacteria; ABF41698; ABF41698; Acid345_2697.
DR   KEGG; aba:Acid345_2697; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_1_3_0; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000002432; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..882
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335101"
FT   BINDING         638..645
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   882 AA;  98057 MW;  3DE4E39C4F2A0355 CRC64;
     MNDPTTPLMK QWAQVKRDHP NALLFFRLGD FYELFFDDAV IAARELQITL TARNKEKGNS
     VPMCGVPYHA AENYISKLIR RGFKVAVCDQ VEDPKLAKKL VKREVTRVMT PGTTADSQLG
     SEENNFLAAV ASHGDFVGFA ALDLSTGEFR ATEFKGSDAR RRIQEELLTL RPREILYGSS
     LPLFDAARPA NAVSGAMPKL ATVEGASWAE TPLEDWVFAP DYAIPLVENH FGVLSLEGFG
     LANKASAASA AGAILHYVRQ TQRGSLHHVD RIGFYERQNC LVLDAVTVRN LELIEPLFTN
     TGEGVTLFRA LDATMTPMGK RLLRAWMLRP SIDTSEINAR LDAIEMQVVD TLGREELRRA
     MDGILDIERL LSRVTLETAN PRDLLALAQC FGRLPKVRAA MQRFTSARFL VLHGLLDDLA
     DLRDRIFTTL VDEPPITLND GGVVREGLDA ALDELRNLSH NSKQFIAQIE ERERKRTGIG
     SLKIKFNNVF GYYLEISNAN KHLAPADYER KQTLVNAERF TTPELKEYEA KVLDAQEKIV
     EIERRIFGEL RTAIAAEARR VRQTGLALAE VDVLANFAHL AATRNYCRPK FDQSGEFELI
     EARHPVIELP ELTGSADRFV PNDLYLNATT HTVIVLTGPN MGGKSTYLRQ AALVAVMAQM
     GSFVPARSAR LSVVDRVFTR IGAADNLARG RSTFMVEMTE TAAILNTATD RSLILLDEVG
     RGTSTYDGLA IAWACIEFLH ARTRAKALFA THYHELTVLA DELSGVKNYH VSVKESGGNV
     VFLRRVEPGA ADKSYGIEVA KLAGLPAEVI ERARAVLKEH ESVERQATSH LSKDERGSDS
     MQLTIFTPLS QKIVDQLKET DLNRLTPIEA LNLLHELKKQ LD