ID   MUTS_LACAC              Reviewed;         856 AA.
AC   Q5FLX5;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=LBA0408;
OS   Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=272621;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700396 / NCK56 / N2 / NCFM;
RX   PubMed=15671160; DOI=10.1073/pnas.0409188102;
RA   Altermann E., Russell W.M., Azcarate-Peril M.A., Barrangou R., Buck B.L.,
RA   McAuliffe O., Souther N., Dobson A., Duong T., Callanan M., Lick S.,
RA   Hamrick A., Cano R., Klaenhammer T.R.;
RT   "Complete genome sequence of the probiotic lactic acid bacterium
RT   Lactobacillus acidophilus NCFM.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:3906-3912(2005).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000033; AAV42299.1; -; Genomic_DNA.
DR   RefSeq; WP_011254144.1; NC_006814.3.
DR   RefSeq; YP_193330.1; NC_006814.3.
DR   AlphaFoldDB; Q5FLX5; -.
DR   SMR; Q5FLX5; -.
DR   STRING; 272621.LBA0408; -.
DR   PRIDE; Q5FLX5; -.
DR   EnsemblBacteria; AAV42299; AAV42299; LBA0408.
DR   GeneID; 56942013; -.
DR   KEGG; lac:LBA0408; -.
DR   PATRIC; fig|272621.13.peg.393; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_1_3_9; -.
DR   OMA; TPMMAQY; -.
DR   BioCyc; LACI272621:G1G49-402-MON; -.
DR   Proteomes; UP000006381; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..856
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224377"
FT   BINDING         600..607
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   856 AA;  95666 MW;  5670E5E8431767E6 CRC64;
     MMEQYYEIKK QYPDAFLFYR VGDFYELFEE DAVKGAQILE LTLTHRSNKT KNPIPMAGVP
     HMAVDTYVNT LVEKGYKVAL CEQLEDPKKA KGMVKRGIIQ LVTPGTMMSE GPNDAKDSNY
     LTSVVTTEKG FGVAYSDLST GEVYATHLKS FEAVSNELLS LRTREVVYNG PLTEQNKEFM
     HKANITVSSP TPIEGEHAEI SYVGQNLTNS AEKKATEQLV GYLLSTQKRS LAHLQVAKSY
     EVNQYLQMSH TVQNNLELVA SAKTGKKMGS LFWVLDKTHT AMGGRLLKQW LARPLLNVDE
     INHREEMVQA LFDGYFTREN AIDALKGVYD LERLTGRIAF GNVNARELLQ LSRSLEAVPT
     ILDALDQSDS DVLKEFAQKI DPLKGVAELI TTTIVKDPPL LTTEGGLIRE GVDKQLDRYR
     DAMNNGKKWL AQMEADERQK TGIENLKVGY NKVFGYYIQV SNGNKNKVPL DRYTRKQTLT
     NAERYITPEL KEHENLILEA QTRSTDLEYD LFVRLREEVK KYIPALQKLG SQLAALDVFC
     GFASVAEQNN YCRPSFHTDN QDIDVVNGRH PVVEKVMTAG SYIPNSVEMD SSTNIYLITG
     PNMSGKSTYM RQMALIAIMA QVGSFVPADS ADLPIFDQIF TRIGAADDLI SGQSTFMVEM
     SEANDALQYA TKRSLVLFDE IGRGTATYDG MALAGAIVKY LHDKVGAKAF FATHYHELTD
     LDETLDHLKN IHVGATEENG KLIFLHKILP GPADQSYGIH VAQLAGLPKS VLREATKLLK
     RLEAQGSEIA PASQQLDLFA QPEVNDSEEV QAEQAVITDT EQNILDDISN LYLADKTPLQ
     IMQLVADWQK DLKDDK