ID   MUTS_LACCB              Reviewed;         857 AA.
AC   B3W9W4;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=LCABL_24170;
OS   Lacticaseibacillus casei (strain BL23) (Lactobacillus casei).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lacticaseibacillus.
OX   NCBI_TaxID=543734;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BL23;
RA   Maze A., Boel G., Bourand A., Loux V., Gibrat J.F., Zuniga M., Hartke A.,
RA   Deutscher J.;
RT   "Lactobacillus casei BL23 complete genome sequence.";
RL   Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; FM177140; CAQ67483.1; -; Genomic_DNA.
DR   RefSeq; WP_012491883.1; NC_010999.1.
DR   AlphaFoldDB; B3W9W4; -.
DR   SMR; B3W9W4; -.
DR   PRIDE; B3W9W4; -.
DR   KEGG; lcb:LCABL_24170; -.
DR   HOGENOM; CLU_002472_4_0_9; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..857
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000093631"
FT   BINDING         608..615
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   857 AA;  94850 MW;  BB84C221DA8D6D51 CRC64;
     MPQKTSETPM MQQYNEIKAQ YPDAFLFYRI GDFYELFNDD AIKGAQLLEL TLTARNKSAD
     DPIPMAGVPH HAVQSYVDIL IDHGYKVAIC EQMEDPKKAV GMVKRAVIQL VTPGTNVDIK
     AGAAKSNNYI TAVMPHAAGY AFAYADVSTG ELKVTDLKSK FALQNELSAL ATKEIVVPEE
     LTDDDAGMLK QGERLLSVQP DAEPTSEGSY VSQELTDPAE AAVVQMLMAY LLNTQKRSLA
     HIQKAVAYQP SAYLEMDQDA RSNLDILQNS RTGRKGDTLL SLLDSTKTAM GGRLLKQWLD
     RPLLDIDAIS VRQNQVQDLL DHFFERSELQ ERLTKVYDLE RLAGRVAFGT VNGRDLIQLQ
     TSLDQIPAIQ DVLGKLDDGS FKALRSKMDP VSDVAGLIRR AIEPEPPISV TDGGLILRGY
     NQKLDSYRDA MKNSKQWIAE LEASERKATG IHTLKIRYNK VFGYFIEVTK SNLDKIPEGR
     YERKQTLTNA ERFITPELKE KETLILEAQE SSTALEYDLF QDIRDKVKAQ IKRLQALAAQ
     ISSLDVLQSF ATVAENSHYV RPTMHAGTHD INVKGGRHPV VEHVLGRDSY IPNDVIMNHD
     TDMLLITGPN MSGKSTYMRQ LALIVIMAQA GSFVPADVAD LPIFDQIFTR IGAADDLANG
     ESTFMVEMLE ANAALSHATA SSLILFDEIG RGTATYDGMA LAQAIIEFLH DHVHAKTLFS
     THYHELTSLS DSLAKLKNVH VGAVEEHGNL VFLHKMMPGP ADKSYGIHVA KLAGLPADLL
     ARADTILKQL EADAPNKTAP APAPQVEEQQ LSLFEEPKPT PKNSPILTKL AKFDLMAATP
     MDAMNFIFDL QKHLKKK