ID   MUTS_LACDA              Reviewed;         856 AA.
AC   Q1G938;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   27-JUN-2006, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Ldb1616;
OS   Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM 20081
OS   / BCRC 10696 / JCM 1002 / NBRC 13953 / NCIMB 11778 / NCTC 12712 / WDCM
OS   00102 / Lb 14).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=390333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11842 / DSM 20081 / BCRC 10696 / JCM 1002 / NBRC 13953 / NCIMB
RC   11778 / NCTC 12712 / WDCM 00102 / Lb 14;
RX   PubMed=16754859; DOI=10.1073/pnas.0603024103;
RA   van de Guchte M., Penaud S., Grimaldi C., Barbe V., Bryson K., Nicolas P.,
RA   Robert C., Oztas S., Mangenot S., Couloux A., Loux V., Dervyn R., Bossy R.,
RA   Bolotin A., Batto J.-M., Walunas T., Gibrat J.-F., Bessieres P.,
RA   Weissenbach J., Ehrlich S.D., Maguin E.;
RT   "The complete genome sequence of Lactobacillus bulgaricus reveals extensive
RT   and ongoing reductive evolution.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:9274-9279(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR954253; CAI98405.1; -; Genomic_DNA.
DR   RefSeq; WP_011544117.1; NZ_JQAV01000002.1.
DR   AlphaFoldDB; Q1G938; -.
DR   SMR; Q1G938; -.
DR   STRING; 390333.Ldb1616; -.
DR   EnsemblBacteria; CAI98405; CAI98405; Ldb1616.
DR   KEGG; ldb:Ldb1616; -.
DR   PATRIC; fig|390333.13.peg.1008; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_1_3_9; -.
DR   OMA; TPMMAQY; -.
DR   BioCyc; LDEL390333:LDB_RS06985-MON; -.
DR   Proteomes; UP000001259; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..856
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000057635"
FT   BINDING         607..614
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   856 AA;  95653 MW;  31ECD0974286E2AA CRC64;
     MPRKATTPMM EQYYQIKDQY PDAFLFYRVG DFYELYEDDA IKGSQILELT LTHRSNKSEN
     PIPMAGVPHM AVDSYVNTLV EKGYKVAICE QLEDPKKAKG MVKRGIIQLV TPGTKMAQGP
     DDSQESNYLT SVVEKAGGYG LAYSDLSTGE IFVTHVKHYA EVVNELLSLR TREVVFAGNL
     SASDRDRLQK ANITVSEPAE LEGEHAEISY VQQKLTDSME KAAVRQLVVY LLATQKRSLA
     HLQVAESFEI GQYLQMANTV QRNLELTQSA TTGRKQGSLF WVLDKTTTAM GGRLLKQWLS
     RPLLSLDRIK QRQQMVQALL DDYFTRENIV DSLKGVYDLE RLSGRVAFGN VNPRELLQLA
     KSLEATKLII QTLVESGNPD LEKYGQGIDP QSELAESITN CLVDQPPISA KDGGIIRAGV
     SEDLDKYREA MNGGKKWLAQ MEMEERQRTG IDNLKIGYNR VFGYFIQVSK GNVAKVPQDR
     YTRKQTLTNA DRYITPELKE HENLILEAES RSTDLEYELF SQLREAVKAH IPDLQELGRQ
     LAALDVFVAF AQDAEEKNYC RPSFSSKNEI AVKNGRHPVV GAVLPAGSYI PNDLVMDEDT
     SIYLITGPNM SGKSTYMRQL ALIAIMAQIG SFVPADSAKL PVFDQVFTRI GAADDLYSGK
     STFMVEMSEA NEALQHASSR SLVLFDEIGR GTATYDGMAL AGAIIKYLHD KVGAKTLFAT
     HYHELTELDE TLLHLKNIHV GATEENGKLI FLHKILPGPA DQSYGIHVAK LAGLPRVVLR
     EASSMLKRLE AEGAREINPS RQQLDLFSPV EVVEENPLKA EQEELLDEIS QVNLNEKTPL
     EVMQLVADWQ QALKEE