ID   MUTS_LACDB              Reviewed;         856 AA.
AC   Q048Y4;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=LBUL_1495;
OS   Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC BAA-365 / Lb-18).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=321956;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-365 / Lb-18;
RX   PubMed=17030793; DOI=10.1073/pnas.0607117103;
RA   Makarova K.S., Slesarev A., Wolf Y.I., Sorokin A., Mirkin B., Koonin E.V.,
RA   Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V.,
RA   Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M.,
RA   Hawkins T., Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A.,
RA   Baldwin K., Lee J.-H., Diaz-Muniz I., Dosti B., Smeianov V., Wechter W.,
RA   Barabote R., Lorca G., Altermann E., Barrangou R., Ganesan B., Xie Y.,
RA   Rawsthorne H., Tamir D., Parker C., Breidt F., Broadbent J.R., Hutkins R.,
RA   O'Sullivan D., Steele J., Unlu G., Saier M.H. Jr., Klaenhammer T.,
RA   Richardson P., Kozyavkin S., Weimer B.C., Mills D.A.;
RT   "Comparative genomics of the lactic acid bacteria.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000412; ABJ58988.1; -; Genomic_DNA.
DR   RefSeq; WP_011678485.1; NC_008529.1.
DR   AlphaFoldDB; Q048Y4; -.
DR   SMR; Q048Y4; -.
DR   KEGG; lbu:LBUL_1495; -.
DR   HOGENOM; CLU_002472_1_3_9; -.
DR   OMA; TPMMAQY; -.
DR   BioCyc; LDEL321956:LBUL_RS07065-MON; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..856
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000057636"
FT   BINDING         607..614
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   856 AA;  95725 MW;  2BA61BF604FAC97E CRC64;
     MPRKATTPMM EQYYQIKDQY PDAFLFYRVG DFYELYEDDA IKGSQILELT LTHRSNKSEN
     PIPMAGVPHM AVDSYVNTLV EKGYKVAICE QLEDPKKAKG MVKRGIIQLV TPGTKMAQGP
     DDSQESNYLT SVVEKAGGYG LAYSDLSTGE IFVTHVKHYA EVVNELLSLR TREVVFAGNL
     SASDRDRLQK ANITVSEPAE LEGEHAEISY VQQKLTDSME KAAVRQLVVY LLATQKRSLA
     HLQVAESFEI GQYLQMANTV QRNLELTQSA TTGRKQGSLF WVLDKTTTAM GGRLLKQWLS
     RPLLSLDRIK QRQQMVQALL DDYFTRENIV DSLKGVYDLE RLSGRVAFGN VNPRELLQLA
     KSLEATKLII QTLVESGNPD LEKYGQGIDP QSELAESITN CLVDQPPISA KDGGIIRAGV
     SEDLDKYREA MNGGKKWLAQ MEMEERQRTG IDNLKIGYNR VFGYFIQVSK GNVAKVPQDR
     YTRKQTLTNA ERYITPELKE HENLILEAES RSTDLEYELF SQLREAVKAH IPDLQELGRQ
     LAALDVFVAF AQDAEEKNYC RPSFSSKNEI AVKNGRHPVV EAVLPAGSYI PNDLVMDEDT
     SIYLITGPNM SGKSTYMRQL ALIAIMAQIG SFVPADSAKL PVFDQIFTRI GAADDLYSGK
     STFMVEMSEA NEALQHASSR SLVLFDEIGR GTATYDGMAL AGAIIKYLHD KVGAKTLFAT
     HYHELTELDE TLLHLKNIHV GATEENGKLI FLHKILPGPA DQSYGIHVAK LAGLPRAVLR
     EASSMLKRLE AEGAREINPS RQQLDLFSPV EVVEENPLKA EQEELLDEIS QVNLNEKTPL
     EVMQLVADWQ QALKEE