ID   MUTS_LACGA              Reviewed;         857 AA.
AC   Q045Q5;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=LGAS_0412;
OS   Lactobacillus gasseri (strain ATCC 33323 / DSM 20243 / BCRC 14619 / CIP
OS   102991 / JCM 1131 / KCTC 3163 / NCIMB 11718 / NCTC 13722 / AM63).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=324831;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33323 / DSM 20243 / BCRC 14619 / CIP 102991 / JCM 1131 / KCTC
RC   3163 / NCIMB 11718 / NCTC 13722 / AM63;
RX   PubMed=17030793; DOI=10.1073/pnas.0607117103;
RA   Makarova K.S., Slesarev A., Wolf Y.I., Sorokin A., Mirkin B., Koonin E.V.,
RA   Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V.,
RA   Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M.,
RA   Hawkins T., Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A.,
RA   Baldwin K., Lee J.-H., Diaz-Muniz I., Dosti B., Smeianov V., Wechter W.,
RA   Barabote R., Lorca G., Altermann E., Barrangou R., Ganesan B., Xie Y.,
RA   Rawsthorne H., Tamir D., Parker C., Breidt F., Broadbent J.R., Hutkins R.,
RA   O'Sullivan D., Steele J., Unlu G., Saier M.H. Jr., Klaenhammer T.,
RA   Richardson P., Kozyavkin S., Weimer B.C., Mills D.A.;
RT   "Comparative genomics of the lactic acid bacteria.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000413; ABJ59817.1; -; Genomic_DNA.
DR   RefSeq; WP_003652283.1; NZ_WBMG01000012.1.
DR   AlphaFoldDB; Q045Q5; -.
DR   SMR; Q045Q5; -.
DR   GeneID; 66468543; -.
DR   KEGG; lga:LGAS_0412; -.
DR   HOGENOM; CLU_002472_4_0_9; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   BioCyc; LGAS324831:G1G6Y-412-MON; -.
DR   Proteomes; UP000000664; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..857
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000008068"
FT   BINDING         608..615
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   857 AA;  96053 MW;  239A666A779FE95E CRC64;
     MAKKDTTPMM KQYYEIKEQY PDAFLFYRVG DFYELFEDDA VKGAQILELT LTHRSNKTKN
     PIPMAGVPHL AVDTYVNTLV EKGYKVALCE QLEDPKKAKG MVKRGIIQLI TPGTMMHERP
     DQAKDSNYLT SVISTNSGFG LAYSDLSTGE TFSTHLTDFE GVANELLSLQ TREVVYNGHL
     TEANKDFLKK ANITVSEPVK VEGEHAEISY VTQNLTDDAE IKATKQLVAY LLSTQKRSLA
     HLQVAQSYEP TQYLQMSHTV QTNLELIKSA KTSKKMGSLF WLLDKTSTAM GGRLLKSWIE
     RPLLSVTEIT RRQEMVQALL DDYFTREKVI DSLKGVYDLE RLTGRIAFGS VNAREMLQLA
     HSLGAIPDIL NSLLETNNPH LQNFAKQIDP LKGIHDLIVN TIVDNPPLLT TEGGLIREGV
     SDQLDRYRDA MNNGKKWLSE MESHEREVTG INNLKVGYNK VFGYYIEVTN SNKDKVPTDR
     YTRKQTLTNA ERYITPDLKE HESLILEAEA KSTGLEYDLF VKLRENVKKY IPALQKLAKQ
     VASLDVLTNF ATVSEQNNYV RPDFTVDKQE INVVNGRHPV VEQVMTAGSY IPNDVKMDQD
     TDIFLITGPN MSGKSTYMRQ MALIAIMAQI GCFVPADSAT LPIFDQIFTR IGAADDLISG
     QSTFMVEMSE ANDALQHATK RSLVLFDEIG RGTATYDGMA LAGAIVKYLH DKVGAKTLFA
     THYHELTDLD QTLKHLKNIH VGATEENGKL IFLHKILPGP ADQSYGIHVA QLAGLPHKVL
     REATTMLKRL EKQGAGELQP ASEQLDLFTA EEASVPAISD DEKDVLDDIQ NVYLADKTPL
     QVMELVAQWQ QELKDKD