ID   MUTS_LACH4              Reviewed;         858 AA.
AC   A8YTH9;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=lhv_0427;
OS   Lactobacillus helveticus (strain DPC 4571).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=405566;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DPC 4571;
RX   PubMed=17993529; DOI=10.1128/jb.01295-07;
RA   Callanan M., Kaleta P., O'Callaghan J., O'Sullivan O., Jordan K.,
RA   McAuliffe O., Sangrador-Vegas A., Slattery L., Fitzgerald G.F.,
RA   Beresford T., Ross R.P.;
RT   "Genome sequence of Lactobacillus helveticus: an organism distinguished by
RT   selective gene loss and IS element expansion.";
RL   J. Bacteriol. 190:727-735(2008).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000517; ABX26635.1; -; Genomic_DNA.
DR   AlphaFoldDB; A8YTH9; -.
DR   SMR; A8YTH9; -.
DR   STRING; 405566.lhv_0427; -.
DR   EnsemblBacteria; ABX26635; ABX26635; lhv_0427.
DR   KEGG; lhe:lhv_0427; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_9; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000000790; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..858
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000071278"
FT   REGION          803..823
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         600..607
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   858 AA;  95580 MW;  3BC400ED821E2723 CRC64;
     MMEQYYEIKK QYPDAFLFYR VGDFYELFED DAVKGAQILE LTLTHRSNKT KNPIPMAGVP
     HMAVDTYVNT LVEKGYKVAL CEQLEDPKKA KGMVKRGIIQ LVTPGTMMNE GPNDAKDSNY
     LTSVVTTKSG FGLAYSDLST GEIYSTHLKS FAAVSNELLS LRTREVVYNG PLTEQSKDFM
     HKANITVSAP TPIEGEHAEI SYVEQNLTNG AEKSATRQLV GYLLSTQKRS LAHLQIAKSY
     EVNQYLQMSH TVQNNLELVA SAKTGKKMGS LFWVLDKTHT AMGGRLLKQW LARPLLNVDI
     INHREKMVQA LLDGYFTREN TIDALKGVYD LERLTGRIAF GNVNARELLQ LSRSLQAVPV
     ILDALNQSDS DVLTDFAKKI DPLKGVAELI STTLVKDPPL LTTEGGLIRD GVDKQLDRYR
     DAMNNGKKWL VQMETDERQK TGIENLKVGF NKVFGYYIQV SNGNKSKVPL DRYTRKQTLT
     NAERYITPEL KEHENLILEA QTRSTDLEYD LFVQLRDEVK KYIPALQKLG NQLAALDVYC
     GFATVAEQNN YCRPSFHTDS QDIDVVNGRH PVVEKVMTAG SYIPNDVKMD SATNIFLITG
     PNMSGKSTYM RQMALIAIMA QVGSFVPADS AALPIFDQIF TRIGAADDLI SGQSTFMVEM
     SEANAALQYA TKRSLVLFDE IGRGTATYDG MALAGAIVKY LHDKVGAKAL FATHYHELTS
     LDETLDYLKN IHVGATEENG KLIFLHKILP GPADQSYGIH VAQLAGLPRA VLREATKLLK
     RLEAQGSELA PVSQQLDLFA QPEAASDEVD DNNSENSPMT DAEQEVLDDI SNLYLADKTP
     LQIMQMVANW QKDLKDDK