ID   MUTS_LACJO              Reviewed;         857 AA.
AC   P61668;
DT   07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2004, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=LJ_0465;
OS   Lactobacillus johnsonii (strain CNCM I-12250 / La1 / NCC 533).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=257314;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CNCM I-1225 / La1 / NCC 533;
RX   PubMed=14983040; DOI=10.1073/pnas.0307327101;
RA   Pridmore R.D., Berger B., Desiere F., Vilanova D., Barretto C.,
RA   Pittet A.-C., Zwahlen M.-C., Rouvet M., Altermann E., Barrangou R.,
RA   Mollet B., Mercenier A., Klaenhammer T., Arigoni F., Schell M.A.;
RT   "The genome sequence of the probiotic intestinal bacterium Lactobacillus
RT   johnsonii NCC 533.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2512-2517(2004).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AE017198; AAS08457.1; -; Genomic_DNA.
DR   RefSeq; WP_011161602.1; NC_005362.1.
DR   AlphaFoldDB; P61668; -.
DR   SMR; P61668; -.
DR   STRING; 257314.LJ_0465; -.
DR   EnsemblBacteria; AAS08457; AAS08457; LJ_0465.
DR   KEGG; ljo:LJ_0465; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_9; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000000581; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..857
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115103"
FT   BINDING         608..615
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   857 AA;  96000 MW;  6A99FCEC899FDF2C CRC64;
     MAKKDTTPMM KQYYEIKEQY PDAFLFYRVG DFYELFEDDA IKGAQILELT LTHRSNKTKN
     PIPMAGVPHL AVDTYVNTLV EKGYKVALCE QLEDPKKAKG MVKRGIIQLI TPGTMMQERP
     DQAKDSNYLT SVISTNSGFG LAYSDLSTGE TFSTHLADFE AVANELLSLQ TREVVYNGHL
     TDLNKDFLKK ANITVSEPVE VEGEHAEISY VAQNLTDDAE IKATKQLVAY LLSTQKRSLA
     HLQVAQSYEP TQYLQMSHTV QTNLELIKSA KTSKKMGSLF WLLDKTSTAM GGRLLKSWIE
     RPLLSVTEIT RRQEMVQALL DDYFTREKVI DSLKGVYDLE RLTGRIAFGS VNAREMLQLA
     HSLGAIPEIL NALLETNNPH LQNFAKQIDP LKGIHDLIVN TIVDNPPLPT TEGGLIREGV
     SEQLDRYRDA MNNGKKWLSE MESHEREVTG INNLKVGYNK VFGYYIEVTN SNKSKVPTDR
     YTRKQTLTNA ERYITPDLKE HEALILEAEA KSTGLEYDLF VKLREDVKKY IPALQKLAKQ
     IASLDVLTNF ATVSEQNNYV RPNFVTDKQE INVVNGRHPV VEQVMTAGSY IPNDVKMDQD
     TNIFLITGPN MSGKSTYMRQ MALIAIMAQI GSFVPADSAT LPIFDQIFTR IGAADDLISG
     QSTFMVEMSE ANDALQHATK RSLVLFDEIG RGTATYDGMA LAGAIVKYLH DKVGAKALFA
     THYHELTDLD QTLKHLKNIH VGATEENGKL IFLHKILPGP ADQSYGIHVA QLAGLPHKVL
     REATTMLKRL EKQGASELQP ASEQLDLFVP EEASAPAISD DEKDVLDEIQ NVYLADKTPL
     QVMELVAQWQ QELKDKD