ID   MUTS_LACLA              Reviewed;         840 AA.
AC   Q9CDK9;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   27-APR-2001, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=DNA mismatch repair protein MutS;
GN   Name=mutS; Synonyms=hexA; OrderedLocusNames=LL2210; ORFNames=L0277;
OS   Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=272623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IL1403;
RX   PubMed=11337471; DOI=10.1101/gr.gr-1697r;
RA   Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J.,
RA   Ehrlich S.D., Sorokin A.;
RT   "The complete genome sequence of the lactic acid bacterium Lactococcus
RT   lactis ssp. lactis IL1403.";
RL   Genome Res. 11:731-753(2001).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000305}.
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DR   EMBL; AE005176; AAK06308.1; -; Genomic_DNA.
DR   PIR; B86901; B86901.
DR   RefSeq; NP_268367.1; NC_002662.1.
DR   RefSeq; WP_010906385.1; NC_002662.1.
DR   AlphaFoldDB; Q9CDK9; -.
DR   SMR; Q9CDK9; -.
DR   STRING; 272623.L0277; -.
DR   PaxDb; Q9CDK9; -.
DR   EnsemblBacteria; AAK06308; AAK06308; L0277.
DR   KEGG; lla:L0277; -.
DR   PATRIC; fig|272623.7.peg.2374; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_9; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000002196; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..840
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115104"
FT   BINDING         601..608
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   840 AA;  94272 MW;  867EFE4F82616DC2 CRC64;
     MAEKISPGMQ QYLDIKQDYP DAFLLFRMGD FYELFYDDAV NAAQILELTL TSRNKNSENP
     IPMAGVPHHA AAEYIDKLVD LGYKVAVAEQ MEDPKKAVGI VKRAVTQVIT PGTTIDTANS
     VDNNFLVAID FKDKHYALSY MDLSTGEFKV TELSEFSAVV GEIASLKARE IVAGFTLDES
     QLKVFERQMN LLISEQLEIP ENLLIDLSGL TALENQVASK LLAYVKETQM RDLSHLQEVE
     HYEIKDFLQM DFATKSSLEL TANKRENKKH GTLYWLLDET KTAMGTRMLR SWIDRPLISN
     SAIQKRMEIV QIFLDHFFER SDLIEALKGV YDLERLASRV SFGKAVPVDF LQLANSLSNV
     PAIKYILGML NEAPLEELKS QLDEIPELSG LINSAISENA SRTITEGGII KKGYNAQLDK
     YREALENGTS WIAKLEADEK AKTGISTLRI DYNRKDGYYF HITQSQLNSV PEHFYRKATL
     KNSERFGSQE LTEIEEIMLE AREKSSSLEY DLFMGLRTET EQYIGRLQAL AKTIAEIDCL
     QSLSVVAEKQ GYIRPTLTDG SRIVEIKGGR HAVVEAVMGA QEYVPNDIEL PEQTDIQLIT
     GPNMSGKSTY MRQFALTVIM AQIGSFVPAE TANLPIFDAI FTRIGASDNL ISGESTFMVE
     MSEANHAIQK ASSRSLIIFD ELGRGTATYD GMALAQAIIE YVHDHIGAKT LFATHYHELT
     DLDEALDHLD NVHVATLEQN GNVTFLHKIT EGPADKSYGI HVAKIAGLPQ PLLERADLIL
     QKLENKPLPA KKVADEQEQL SLFDFTENSS EIIEKIKRQN VDNMTAREAL NFLWELKDSL