ID   MUTS_LACLM              Reviewed;         840 AA.
AC   A2RP10;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=llmg_2491;
OS   Lactococcus lactis subsp. cremoris (strain MG1363).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus; Lactococcus cremoris subsp. cremoris.
OX   NCBI_TaxID=416870;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MG1363;
RX   PubMed=17307855; DOI=10.1128/jb.01768-06;
RA   Wegmann U., O'Connell-Motherway M., Zomer A., Buist G., Shearman C.,
RA   Canchaya C., Ventura M., Goesmann A., Gasson M.J., Kuipers O.P.,
RA   van Sinderen D., Kok J.;
RT   "The complete genome sequence of the lactic acid bacterial paradigm
RT   Lactococcus lactis subsp. cremoris MG1363.";
RL   J. Bacteriol. 189:3256-3270(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AM406671; CAL99055.1; -; Genomic_DNA.
DR   RefSeq; WP_011836120.1; NZ_WJVF01000029.1.
DR   AlphaFoldDB; A2RP10; -.
DR   SMR; A2RP10; -.
DR   STRING; 416870.llmg_2491; -.
DR   PRIDE; A2RP10; -.
DR   EnsemblBacteria; CAL99055; CAL99055; llmg_2491.
DR   KEGG; llm:llmg_2491; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_9; -.
DR   OMA; TPMMAQY; -.
DR   PhylomeDB; A2RP10; -.
DR   BioCyc; LLAC416870:LLMG_RS12515-MON; -.
DR   Proteomes; UP000000364; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..840
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335172"
FT   BINDING         601..608
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   840 AA;  94300 MW;  AC5164ECA299B421 CRC64;
     MAEKISPGMQ QYLDIKQDYP DAFLLFRMGD FYELFYEDAV NAAQILELTL TSRNKNSENP
     IPMAGVPHHA ATEYIDKLVD LGYKVAVAEQ MEDPKKAVGI VKRAVTQVIT PGTTIDTANS
     VDNNFLVAID FKAKRYALSY MDLSTGEFKV TELSEFSAVV GEIASLKARE IVVGFPLDEA
     QVKVFERQMN LLISEQFEIP ENLLIELSGL TALENQAASK LLAYVKETQM RDLSHLQEVE
     HYEIKDFLQM DFATKSSLEL TANKRENKKH GTLYWLLDET KTAMGTRMLR SWIDRPLVSN
     SAIQKRMEIV QVFLDHFFER SDLIEALKGV YDLERLASRV SFGKAVPVDF LQLANSLSNV
     PAIKNILEVL DEMPLNELRS QLDEIPELSG LINSAISENA SRTITEGGII KKGYNVQLDK
     YREALENGTS WIAKLEADEK AKTGISTLRI DYNRKDGYYF HITQSQLNSV PEHFYRKATL
     KNSERFGSQE LTEIEEIMLE AREKSSSLEY DLFMGLRAET EQYIGRLQAL AKTIAEIDCL
     QSLSVVAEKQ GYIRPTLTEG SRIVEIKGGR HAVVEAVMGA QEYVPNDIEL PEQTDIQLIT
     GPNMSGKSTY MRQFALTVIM AQIGSFVPAE TANLPIFDAI FTRIGASDNL ISGESTFMVE
     MSEANHAIQK ATSRSLIIFD ELGRGTATYD GMALAQAIIE YVHEHIGAKT LFATHYHELT
     DLDKELDHLD NVHVATLEQN GNVTFLHKIT DGPADKSYGI HVAKIAGLPQ TLLERADLIL
     QKLENKPLPA KKVADEQEQL SLFDFAENSS EIIEKIKGQN VDNMTAREAL NFLWELKDSL