ID   MUTS_LACLS              Reviewed;         840 AA.
AC   Q02VS3;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=LACR_2519;
OS   Lactococcus lactis subsp. cremoris (strain SK11).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus; Lactococcus cremoris subsp. cremoris.
OX   NCBI_TaxID=272622;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SK11;
RX   PubMed=17030793; DOI=10.1073/pnas.0607117103;
RA   Makarova K.S., Slesarev A., Wolf Y.I., Sorokin A., Mirkin B., Koonin E.V.,
RA   Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V.,
RA   Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M.,
RA   Hawkins T., Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A.,
RA   Baldwin K., Lee J.-H., Diaz-Muniz I., Dosti B., Smeianov V., Wechter W.,
RA   Barabote R., Lorca G., Altermann E., Barrangou R., Ganesan B., Xie Y.,
RA   Rawsthorne H., Tamir D., Parker C., Breidt F., Broadbent J.R., Hutkins R.,
RA   O'Sullivan D., Steele J., Unlu G., Saier M.H. Jr., Klaenhammer T.,
RA   Richardson P., Kozyavkin S., Weimer B.C., Mills D.A.;
RT   "Comparative genomics of the lactic acid bacteria.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000425; ABJ73949.1; -; Genomic_DNA.
DR   RefSeq; WP_011677258.1; NC_008527.1.
DR   AlphaFoldDB; Q02VS3; -.
DR   SMR; Q02VS3; -.
DR   EnsemblBacteria; ABJ73949; ABJ73949; LACR_2519.
DR   KEGG; llc:LACR_2519; -.
DR   HOGENOM; CLU_002472_4_0_9; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000000240; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..840
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335173"
FT   BINDING         601..608
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   840 AA;  94209 MW;  7595CDD348440A92 CRC64;
     MAEKISPGMQ QYLDIKQDYP DAFLLFRMGD FYELFYEDAV NAAQILELTL TSRNKNSENP
     IPMAGVPHHA ATEYIDKLVD LGYKVAVAEQ MEDPKKAVGI VKRAVTQVIT PGTTIDTANS
     VDNNFLVAID FKAKRYALSY MDLSTGEFKV TELSEFSAVV GGIASLKARE IVVGFPLDEA
     QVKVFERQMN LLISEQFEIP ENLLIELSGL TALENQAASK LLAYVKETQM RDLSHLQEVE
     HYEIKDFLQL DFATKSSLEL TANKRENKKH GTLYWLLDET KTAMGTRMLR SWIDRPLVSN
     SAIQKRMEIV QVFLDHFFER SDLIEALKGV YDLERLASRV SFGKAVPVDF LQLANSLSNV
     PAIKNILEVL DETSLNELRS QLDEIPELSG LINSAISENA SRTITEGGII KKGYNVQLDK
     YREALENGTS WIAKLEADEK AKTGISTLRI DYNRKDGYYF HITQSQLNSV PEHFYRKATL
     KNSERFGSQE LTEIEEIMLE AREKSSSLEY DLFMGLRAET EQYIGRLQAL AKTIAEIDCL
     QSLSVVAEKQ GYIRPTLTEG SRIVEIKGGR HAVVEAVMGA QEYVPNDIEL PEQTDIQLIT
     GPNMSGKSTY MRQFALTVIM AQIGSFVPAK TANLPIFDAI FTRIGASDNL ISGESTFMVE
     MSEANHAIQK ATSRSLIIFD ELGRGTATYD GMALAQAIIE YVHEYIGAKT LFATHYHELT
     DLDKELDHLD NVHVATLEQN GNVTFLHKIT DGPADKSYGI HVAKIAGLPQ TLLERADLIL
     QKLENKPLPA KKIADEQEQL SLFDFAENSS EIIEKIKGQN VDNMTAREAL NFLWELKDSL