ID   MUTS_LACP3              Reviewed;         857 AA.
AC   Q035Z2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=LSEI_2235;
OS   Lacticaseibacillus paracasei (strain ATCC 334 / BCRC 17002 / CCUG 31169 /
OS   CIP 107868 / KCTC 3260 / NRRL B-441) (Lactobacillus paracasei).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lacticaseibacillus.
OX   NCBI_TaxID=321967;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 334 / BCRC 17002 / CCUG 31169 / CIP 107868 / KCTC 3260 / NRRL
RC   B-441;
RX   PubMed=17030793; DOI=10.1073/pnas.0607117103;
RA   Makarova K.S., Slesarev A., Wolf Y.I., Sorokin A., Mirkin B., Koonin E.V.,
RA   Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V.,
RA   Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M.,
RA   Hawkins T., Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A.,
RA   Baldwin K., Lee J.-H., Diaz-Muniz I., Dosti B., Smeianov V., Wechter W.,
RA   Barabote R., Lorca G., Altermann E., Barrangou R., Ganesan B., Xie Y.,
RA   Rawsthorne H., Tamir D., Parker C., Breidt F., Broadbent J.R., Hutkins R.,
RA   O'Sullivan D., Steele J., Unlu G., Saier M.H. Jr., Klaenhammer T.,
RA   Richardson P., Kozyavkin S., Weimer B.C., Mills D.A.;
RT   "Comparative genomics of the lactic acid bacteria.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000423; ABJ70980.1; -; Genomic_DNA.
DR   RefSeq; WP_011674831.1; NC_008526.1.
DR   RefSeq; YP_807422.1; NC_008526.1.
DR   AlphaFoldDB; Q035Z2; -.
DR   SMR; Q035Z2; -.
DR   STRING; 321967.LSEI_2235; -.
DR   EnsemblBacteria; ABJ70980; ABJ70980; LSEI_2235.
DR   GeneID; 61270358; -.
DR   KEGG; lca:LSEI_2235; -.
DR   PATRIC; fig|321967.11.peg.2197; -.
DR   HOGENOM; CLU_002472_4_0_9; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000001651; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..857
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000008067"
FT   BINDING         608..615
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   857 AA;  94792 MW;  0F85529FE61C017F CRC64;
     MPQKTSETPM MQQYNEIKAQ YPDAFLFYRI GDFYELFNDD AIKGAQLLEL TLTARNKSAD
     DPIPMAGVPH HAVQSYVDIL IDHGYKVAIC EQMEDPKKAV GMVKRAVIQL VTPGTNVDIK
     AGAAKSNNYI TAVMPHAAGY AFAYADVSTG ELKVTDLKSK FALQNELSAL ATKEIVVPEE
     LTDDDAGMLK QGERLLSVQP DAEPTSEGSY VSQALTDPAE AAVVQMLMAY LLNTQKRSLA
     HIQKAVAYQP SAYLEMDQDA RSNLDILQNS RTGRKGDTLL SLLDSTKTAM GGRLLKQWLD
     RPLLDIDAIS VRQNQVQDLL DHFFERSELQ ERLTKVYDLE RLAGRVAFGT VNGRDLIQLQ
     TSLDQIPAIQ DVLGKLDDGS FKALRSKMDP VSDVAGLIRR AIEPEPPISV TDGGLILRGY
     NQKLDSYRDA MKNSKQWIAE LEASERKATG IHTLKIRYNK VFGYFIEVTK SNLDKIPEGR
     YERKQTLTNA ERFITPELKE KETLILEAQE SSTALEYDLF QDIRDKVKAQ IKRLQALAAQ
     ISSLDVLQSF ATVAENSHYV RPTMHAGTHD INVKGGRHPV VEHVLGRDSY IPNDVIMNHD
     TDMLLITGPN MSGKSTYMRQ LALIVIMAQA GSFVPADVAD LPIFDQIFTR IGAADDLANG
     ESTFMVEMLE ANAALSHATA SSLILFDEIG RGTATYDGMA LAQAIIEFLH DHVHAKTLFS
     THYHELTSLS DSLAKLKNVH VGAVEEHGNL VFLHKMMPGP ADKSYGIHVA KLAGLPADLL
     ARADTILKQL EADAPNKTAP APAPQVEEQQ LSLFEEPKPT PKNSPILTKL AKFDLMAATP
     MDAMNFIFDL QKHLKKK