ID   MUTS_LACP7              Reviewed;         932 AA.
AC   A9KL10;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Cphy_2381;
OS   Lachnoclostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg)
OS   (Clostridium phytofermentans).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Lachnospiraceae.
OX   NCBI_TaxID=357809;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700394 / DSM 18823 / ISDg;
RA   Leschine S.B., Warnick T.A., Blanchard J.L., Schnell D.J., Petit E.L.,
RA   LaTouf W.G., Copeland A., Lucas S., Lapidus A., Barry K.,
RA   Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T.,
RA   Bruce D., Detter J.C., Han C., Kuske C., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Kim E.A., Richardson P.;
RT   "Complete genome sequence of Clostridium phytofermentans ISDg.";
RL   Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000885; ABX42742.1; -; Genomic_DNA.
DR   RefSeq; WP_012200396.1; NC_010001.1.
DR   AlphaFoldDB; A9KL10; -.
DR   SMR; A9KL10; -.
DR   STRING; 357809.Cphy_2381; -.
DR   PRIDE; A9KL10; -.
DR   EnsemblBacteria; ABX42742; ABX42742; Cphy_2381.
DR   KEGG; cpy:Cphy_2381; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_0_9; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000000370; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..932
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335143"
FT   BINDING         620..627
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   932 AA;  105337 MW;  1C76B089AD3BD54B CRC64;
     MAQLTPMMQQ YVETKEQYKD CILFYRLGDF YEMFFEDALV ASKELEITLT GKNCGQEERA
     PMCGIPYHAA EGYISKLIGK GYKVAICEQV EDPKLAKGIV KREVIRIVTP GTNLNTQTLD
     ETRNNYLMGI IFTDEHCGIS TVDITTGDYY VTEVENNRKI LDEIYKYTPS EIVCNPEFFH
     CGLDVEDLKN RYQIAVSTFE DWYYDSEQSV KTLKEHFKVG SLDGLGLKDY SVGVNAAGAI
     LKYLYNTQKN SLSHLTHITP YVTSRYMVID SSSRRNLELT ETLREKQKRG SLLWVLDKTK
     TAMGARMLRS FVEQPLITMD EISARYDAIS ELNDNVITRE EIREYLNYIY DLERLMGKIS
     YKSANPRDLI AFASSLSMLP HIKYLLSTCE SALLKQIHEE MDALDDLQNL IDRSIAEEPP
     IGIKEGGIIK EGFHTEVDTL RKAKTEGKVW LAELEAKEKE QTGIKNLKVK YNRVFGYYLE
     VTNSYANLVP ENWIRKQTLS NAERYTTPEL KELEDKILNA EDRLFSLEYD LFAEIRDQIA
     EEVKRIQKTA KAVANIDAFA SLAYVAERNQ FIRPELNTNG TIDIKEGRHP VVEQMIPNDM
     FVSNDTYLDN AEKRISIITG PNMAGKSTYM RQTALIVLMA QVGSFVPASY ANIGIVDRIF
     TRVGASDDLA SGQSTFMVEM TEVANILRNA TKNSLLILDE IGRGTSTFDG LSIAWAVIEH
     ISNTSMLGAK TLFATHYHEL TELEGKISGV NNYCIAVKEQ GEDIVFLRKI IGGGADKSYG
     IQVAKLAGVP NSVLVRAREI VDQLSENDIA EKARHIVSAA EISNLTPETE GEVNTNKMYT
     TKVNATEVIT TEVNTAKMNT TEMVSNQESV EQPRNFGQMS FFITEDTKQK KASSEFSEKL
     VQEINQFDLA NMTPVEALLK LDKLQKKIRS HT