MUTS_LACPL
ID MUTS_LACPL Reviewed; 896 AA.
AC Q88UZ7; F9UQK9;
DT 31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; Synonyms=hexA;
GN OrderedLocusNames=lp_2298;
OS Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
OS (Lactobacillus plantarum).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactiplantibacillus.
OX NCBI_TaxID=220668;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-793 / NCIMB 8826 / WCFS1;
RX PubMed=12566566; DOI=10.1073/pnas.0337704100;
RA Kleerebezem M., Boekhorst J., van Kranenburg R., Molenaar D., Kuipers O.P.,
RA Leer R., Tarchini R., Peters S.A., Sandbrink H.M., Fiers M.W.E.J.,
RA Stiekema W., Klein Lankhorst R.M., Bron P.A., Hoffer S.M.,
RA Nierop Groot M.N., Kerkhoven R., De Vries M., Ursing B., De Vos W.M.,
RA Siezen R.J.;
RT "Complete genome sequence of Lactobacillus plantarum WCFS1.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:1990-1995(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=ATCC BAA-793 / NCIMB 8826 / WCFS1;
RX PubMed=22156394; DOI=10.1128/jb.06275-11;
RA Siezen R.J., Francke C., Renckens B., Boekhorst J., Wels M.,
RA Kleerebezem M., van Hijum S.A.;
RT "Complete resequencing and reannotation of the Lactobacillus plantarum
RT WCFS1 genome.";
RL J. Bacteriol. 194:195-196(2012).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL935263; CCC79498.1; -; Genomic_DNA.
DR RefSeq; WP_011101708.1; NC_004567.2.
DR RefSeq; YP_004890012.1; NC_004567.2.
DR AlphaFoldDB; Q88UZ7; -.
DR SMR; Q88UZ7; -.
DR STRING; 220668.lp_2298; -.
DR PRIDE; Q88UZ7; -.
DR EnsemblBacteria; CCC79498; CCC79498; lp_2298.
DR KEGG; lpl:lp_2298; -.
DR PATRIC; fig|220668.9.peg.1942; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_4_0_9; -.
DR OMA; TPMMAQY; -.
DR PhylomeDB; Q88UZ7; -.
DR BioCyc; LPLA220668:G1GW0-1982-MON; -.
DR Proteomes; UP000000432; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.420.110; -; 1.
DR Gene3D; 3.40.1170.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361; PTHR11361; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; SSF48334; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF53150; SSF53150; 1.
DR SUPFAM; SSF55271; SSF55271; 1.
DR TIGRFAMs; TIGR01070; mutS1; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..896
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_0000115105"
FT REGION 809..835
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 607..614
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 896 AA; 99980 MW; 2B37FD1913EE2D4D CRC64;
MPQKTKDTPM MRQYFAVKNQ YPDAFLFYRL GDFYEMFFDD AIKGAQLLEL TLTTRNHSAE
NPIPMCGVPH RAVQNYIDIL VDKGYKVAIC EQMEDPKLAK GMVKREVIQL VTPGTTLERG
AEQAKTNNYL TALIQRDQQY GFAYADLSTG ELKTSVLTTN DTLINELTSL QTKEIVVDDS
VASDLRDQIK TLGILISEQN NVTPQAQLSY LTQDLTVDLE QQVVERLLMY ITVTQKRSLA
HLQKAIAYEP SYFLKLDHNS KYNLELMKSI RTGKKQGTLL WLLDETKTAM GGRLLKQWID
RPLIVKADIE TRQNKVATLL DHYFERSNLQ EELTKVYDLE RLAGRVAFGS VNGRDLVQLK
TSLRQIPKIR YILSELDTQV FNDEVNQLDP VEDVADLIDA AIVEDAPLSV TDGGVIKDGY
NEQLDQYRDA MNNGKKWIAE LEAQERATTG IKNLKIGFNR VFGYYIEVTK ANLAQLPKDR
YERKQTLTNA ERFSTPELKS HESLILEAES HSTDLEYQLF TKVRETVKKA IQRLQTLAKA
VAAIDVLQSF AVVSEDYHFV RPKLTKSHDL KIVDGRHPVV EKVMGNQSYV PNNVTMSPDE
TVLLITGPNM SGKSTYMRQL ALTVIMAQIG CFVPAKSAQL PIFDQIFTRI GATDDLISGQ
STFMVEMQEA NNALQHATAN SLVLFDEIGR GTATYDGMAL AQAIIEFVHN HIHAKTLFST
HYHELTALDQ ELSGLRNVHV GATEQDGELV FLHKVEPGAA DKSYGVHVAK LAGMPTSLLE
RANKILTSLE NQTSTVSTTA ASIAASDAAN SVAPNTAASM PVEAADESQP VESETPVAEA
PVAEAGDEQL SLFAEPAVTD AKGEKVLQQL KTLNLMAMTP MDVMNQLYKW QQKLGK
