ID   MUTS_LATSS              Reviewed;         867 AA.
AC   Q38YR4;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=LCA_0362;
OS   Latilactobacillus sakei subsp. sakei (strain 23K) (Lactobacillus sakei
OS   subsp. sakei).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Latilactobacillus.
OX   NCBI_TaxID=314315;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=23K;
RX   PubMed=16273110; DOI=10.1038/nbt1160;
RA   Chaillou S., Champomier-Verges M.-C., Cornet M., Crutz-Le Coq A.-M.,
RA   Dudez A.-M., Martin V., Beaufils S., Darbon-Rongere E., Bossy R., Loux V.,
RA   Zagorec M.;
RT   "The complete genome sequence of the meat-borne lactic acid bacterium
RT   Lactobacillus sakei 23K.";
RL   Nat. Biotechnol. 23:1527-1533(2005).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CR936503; CAI54663.1; -; Genomic_DNA.
DR   RefSeq; WP_011374071.1; NC_007576.1.
DR   AlphaFoldDB; Q38YR4; -.
DR   SMR; Q38YR4; -.
DR   STRING; 314315.LCA_0362; -.
DR   EnsemblBacteria; CAI54663; CAI54663; LCA_0362.
DR   KEGG; lsa:LCA_0362; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_1_3_9; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   BioCyc; LSAK314315:LCA_RS01725-MON; -.
DR   Proteomes; UP000002707; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..867
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224378"
FT   BINDING         609..616
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   867 AA;  96749 MW;  F798ADC75D9D7066 CRC64;
     MPQKTKETPM MAQYQKVKDQ YPDAFLFYRL GDFYELFNDD AVKASQLLEL TLTARNKNAA
     DPIPMCGVPH HAAQNYIDIL VDQGYKVAIC EQMEDPKTAK GMVKREVVQL VTPGTVMDEK
     AGHAKQNNYL TAVVAQGDQF GFAYTDLSTG EMKVSQISSL DVLLNEMLSL QTKEVVVNHD
     VPSEVVQAFV QQQILVSYQD EGADTAEVSF VSQNISQPLA LAVIKQLVVY LATTQKRHLG
     HLQRAQAYEP SQYLKLDHSA KMNLELTASL RTGHKSGTLL WLLDETKTAM GGRLLKQWLE
     RPLLDLNQIK NRQNQVASFL QHYFERTNLQ EALTKVYDLE RLAGRVAFGS VNGRDLIQLK
     TSLEQIPKIK DVLTGINETQ AFDQALTRLD PVDDVRTLIE TAINPDSPIS VTDGGIIQDG
     YDEQLDQYRN AMSNGKQWLA QLEAQEREAT GIHNLKIGFN RVFGYYIEVT RANLSSLPEG
     RYERKQTLTN AERFITPELK EKEQLILEAE ERSTALEYEL FTQVREQVKL QIERLQTLAK
     GVAALDVLQS FAVVSESYHY VQPTLRTDSR EIDLVDGRHP VVEKVLGRQK YIPNAVQMGK
     ETDMLLITGP NMSGKSTYMR QLALTVIMAQ MGCFVPAKSA NLPVFDQIFT RIGAADDLIS
     GQSTFMVEMM EANRAIMSAT ANSLILFDEI GRGTATYDGM ALAQAIIEYI HDHVHAKTLF
     STHYHELTAL ADTLTALRNV HVGAVEENGE LVFLHKMLAG PADKSYGIHV AKLAGMPETL
     LQRADVILGQ LEDKPKAPVQ PATVAPAQPA AAAVEEQMAL FEPEVAAPVD KKTDKVVAAI
     KNFDLMSATP LEALNQLYEW QKQLNKH