ID   MUTS_LAWIP              Reviewed;         893 AA.
AC   Q1MRT4;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=LI0236;
OS   Lawsonia intracellularis (strain PHE/MN1-00).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfovibrionales;
OC   Desulfovibrionaceae; Lawsonia.
OX   NCBI_TaxID=363253;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PHE/MN1-00;
RA   Kaur K., Zhang Q., Beckler D., Munir S., Li L., Kinsley K., Herron L.,
RA   Peterson A., May B., Singh S., Gebhart C., Kapur V.;
RT   "The complete genome sequence of Lawsonia intracellularis: the causative
RT   agent of proliferative enteropathy.";
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AM180252; CAJ54292.1; -; Genomic_DNA.
DR   RefSeq; WP_011526318.1; NC_008011.1.
DR   AlphaFoldDB; Q1MRT4; -.
DR   SMR; Q1MRT4; -.
DR   STRING; 363253.LI0236; -.
DR   KEGG; lip:LI0236; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_7; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000002430; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..893
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000008070"
FT   BINDING         638..645
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   893 AA;  101808 MW;  3452EDFF0F792543 CRC64;
     MNESSHRITP MLEQYLSIKS NYPDTLLFYR MGDFYELFFE DAETAARELQ IALTARNPRA
     ENPVPMCGVP WHAADSYIHQ LIQKGYKVAL CEQTEDFRES KGLVQRKVTR VFTSATTTEE
     TSLDPKTHTY LGAMYWDEEV NIGAFCWADV STGLWTGIQV KKKSELWQWI QKILPKELLF
     PEKYELPATA KLIEIQFVPL PYKTHFEYPQ AVKRLLQAQG VADLEALGLE KHTILVQACG
     ALVAYLEQTQ LQDVNHLMPF KPLDIGKYVI LDEITEKNLE LFKRVNGKKG VGTLIHVLDH
     TLTPMGGRLL EERLHHPWRD ITTILENQSV LEWLILYKEN MKKLQDALKA IYDLERLSTR
     IVLNRTSPKD LLALKNTLLI LPRVKDALIV EINVKDNRYI TIDESILSTM PTILRQLLTK
     WDNISDYAEK LDKALDENPP NSIVEGGLFK LGFNAELDEL MDLLEHGESK LQALLEKEQK
     VNNLPRLKIG FNRVFGYYFE LTKSAGTPPS HFVRRQTLAN AERYTTEELK DLEERLLSAT
     EKRNTLEYKL FQKLREELVS IRPRILFMAS LIAQLDLWQS LADVAIRHNW NKPTLLTNNN
     IFIREGRHPV IESIIGKSVF VPNDLVMDET RRMLLITGPN MAGKSTVLRQ TAIICLLAHM
     GSFVPATEAQ IGICDRIFSR VGASDNLARG QSTFMVEMME TARILRQATS RSLVILDEIG
     RGTSTFDGLA LAWAVAEDLV CKDHDGVRTL FATHYHELTA LEEKLTGVHT MTIAIRHWND
     ELVFLYRLIP GPADRSYGIE VARLAGVPQS VIQRAKIILT QLEQTHQQPR SLLNLLPGVV
     QNANEELSKQ DVKVVEHPVV TLLKEMNPET LTPLDALKSL VEWKLLYGTT HAT