MUTS_LAWIP
ID MUTS_LAWIP Reviewed; 893 AA.
AC Q1MRT4;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=LI0236;
OS Lawsonia intracellularis (strain PHE/MN1-00).
OC Bacteria; Proteobacteria; Deltaproteobacteria; Desulfovibrionales;
OC Desulfovibrionaceae; Lawsonia.
OX NCBI_TaxID=363253;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PHE/MN1-00;
RA Kaur K., Zhang Q., Beckler D., Munir S., Li L., Kinsley K., Herron L.,
RA Peterson A., May B., Singh S., Gebhart C., Kapur V.;
RT "The complete genome sequence of Lawsonia intracellularis: the causative
RT agent of proliferative enteropathy.";
RL Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR EMBL; AM180252; CAJ54292.1; -; Genomic_DNA.
DR RefSeq; WP_011526318.1; NC_008011.1.
DR AlphaFoldDB; Q1MRT4; -.
DR SMR; Q1MRT4; -.
DR STRING; 363253.LI0236; -.
DR KEGG; lip:LI0236; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_3_1_7; -.
DR OMA; TPMMAQY; -.
DR OrthoDB; 15991at2; -.
DR Proteomes; UP000002430; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.420.110; -; 1.
DR Gene3D; 3.40.1170.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361; PTHR11361; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; SSF48334; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF53150; SSF53150; 1.
DR SUPFAM; SSF55271; SSF55271; 1.
DR TIGRFAMs; TIGR01070; mutS1; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..893
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_1000008070"
FT BINDING 638..645
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 893 AA; 101808 MW; 3452EDFF0F792543 CRC64;
MNESSHRITP MLEQYLSIKS NYPDTLLFYR MGDFYELFFE DAETAARELQ IALTARNPRA
ENPVPMCGVP WHAADSYIHQ LIQKGYKVAL CEQTEDFRES KGLVQRKVTR VFTSATTTEE
TSLDPKTHTY LGAMYWDEEV NIGAFCWADV STGLWTGIQV KKKSELWQWI QKILPKELLF
PEKYELPATA KLIEIQFVPL PYKTHFEYPQ AVKRLLQAQG VADLEALGLE KHTILVQACG
ALVAYLEQTQ LQDVNHLMPF KPLDIGKYVI LDEITEKNLE LFKRVNGKKG VGTLIHVLDH
TLTPMGGRLL EERLHHPWRD ITTILENQSV LEWLILYKEN MKKLQDALKA IYDLERLSTR
IVLNRTSPKD LLALKNTLLI LPRVKDALIV EINVKDNRYI TIDESILSTM PTILRQLLTK
WDNISDYAEK LDKALDENPP NSIVEGGLFK LGFNAELDEL MDLLEHGESK LQALLEKEQK
VNNLPRLKIG FNRVFGYYFE LTKSAGTPPS HFVRRQTLAN AERYTTEELK DLEERLLSAT
EKRNTLEYKL FQKLREELVS IRPRILFMAS LIAQLDLWQS LADVAIRHNW NKPTLLTNNN
IFIREGRHPV IESIIGKSVF VPNDLVMDET RRMLLITGPN MAGKSTVLRQ TAIICLLAHM
GSFVPATEAQ IGICDRIFSR VGASDNLARG QSTFMVEMME TARILRQATS RSLVILDEIG
RGTSTFDGLA LAWAVAEDLV CKDHDGVRTL FATHYHELTA LEEKLTGVHT MTIAIRHWND
ELVFLYRLIP GPADRSYGIE VARLAGVPQS VIQRAKIILT QLEQTHQQPR SLLNLLPGVV
QNANEELSKQ DVKVVEHPVV TLLKEMNPET LTPLDALKSL VEWKLLYGTT HAT