ID   MUTS_LEGPA              Reviewed;         846 AA.
AC   Q5X4B2;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=lpp1768;
OS   Legionella pneumophila (strain Paris).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales;
OC   Legionellaceae; Legionella.
OX   NCBI_TaxID=297246;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Paris;
RX   PubMed=15467720; DOI=10.1038/ng1447;
RA   Cazalet C., Rusniok C., Brueggemann H., Zidane N., Magnier A., Ma L.,
RA   Tichit M., Jarraud S., Bouchier C., Vandenesch F., Kunst F., Etienne J.,
RA   Glaser P., Buchrieser C.;
RT   "Evidence in the Legionella pneumophila genome for exploitation of host
RT   cell functions and high genome plasticity.";
RL   Nat. Genet. 36:1165-1173(2004).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CR628336; CAH12920.1; -; Genomic_DNA.
DR   RefSeq; WP_011214063.1; NC_006368.1.
DR   AlphaFoldDB; Q5X4B2; -.
DR   SMR; Q5X4B2; -.
DR   KEGG; lpp:lpp1768; -.
DR   LegioList; lpp1768; -.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..846
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224380"
FT   BINDING         610..617
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   846 AA;  94808 MW;  10520D2F5CAD1C5D CRC64;
     MSSSHTPMMQ QYLRIKTDYP DMLLFYRMGD FYELFFDDAK RASQLLDLTL THRGQSADKP
     IPMAGVPYHA VENYLARLLK KGESVAICEQ IGDPATSKGP VERQVTRIIT PGTVTDEALL
     DARKDNILLA IHTQKQKIGI AWVDLGGGRF HLQELTEEHQ LNAELVRLQP AELLCKESTP
     LPSFCSNFAV KFRPGWEFDA SNAHKLLCEQ FSVTDLSAFG EQNYPTALIA AGALLAYLKT
     TQKQSLPHLT TLTLEQSEDY LQLDASTQKH LELFENIHGG GEHCLLSILD KTACAMGSRL
     LKRWLGKPLK QHAIIQTRQQ AIKEIIFLQQ DVSLHQLIKQ CADVERIVSR IALKSARPRD
     LVSLLQTLTL LPAIHDELQE NKSLLINEIK KEISPLPLLQ QLLETAIIDN PPMLIRDGGV
     IAPGFDEELD ELRNLSSNAH ETLVKLEQEE KNRTGLSTLK LGYNSVQGFY IELSKAQAQN
     APPHFHRKQT LKNVERYITP ELKLFEDKVL SAQSKALARE KWLYDNLLEE IQQYIPELSD
     LAKSLAQLDV LVTLAERAQS LNWNCPNLVP ESGIMIQAGR HPVIEPLLQE RFIANDLELK
     PNQNMLLITG PNMGGKSTYM RQTALIVLLS HIGSFVPADE VTLGPLDRIF TRIGASDDLS
     SGRSTFMVEM TETAQILRQA TSQSLVLIDE IGRGTSTYDG MALAYASCAF LASTIKAYTL
     FSTHYLELTE LPKEFSCIRN VHLQASIKTG QIVFLYRVEE GCANRSYGLE VAELAGIPKE
     VLKLAHEHLN QIQDTQSILV QTQIIKPPTS PVLTELKKID PDRLTAKEAL DLIYKLKHLE
     CAESIN