ID   MUTS_LEGPH              Reviewed;         846 AA.
AC   Q5ZUJ3;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 2.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=lpg1805;
OS   Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC
OS   33152 / DSM 7513).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales;
OC   Legionellaceae; Legionella.
OX   NCBI_TaxID=272624;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Philadelphia 1 / ATCC 33152 / DSM 7513;
RX   PubMed=15448271; DOI=10.1126/science.1099776;
RA   Chien M., Morozova I., Shi S., Sheng H., Chen J., Gomez S.M., Asamani G.,
RA   Hill K., Nuara J., Feder M., Rineer J., Greenberg J.J., Steshenko V.,
RA   Park S.H., Zhao B., Teplitskaya E., Edwards J.R., Pampou S., Georghiou A.,
RA   Chou I.-C., Iannuccilli W., Ulz M.E., Kim D.H., Geringer-Sameth A.,
RA   Goldsberry C., Morozov P., Fischer S.G., Segal G., Qu X., Rzhetsky A.,
RA   Zhang P., Cayanis E., De Jong P.J., Ju J., Kalachikov S., Shuman H.A.,
RA   Russo J.J.;
RT   "The genomic sequence of the accidental pathogen Legionella pneumophila.";
RL   Science 305:1966-1968(2004).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAU27884.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE017354; AAU27884.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_014844166.1; NC_002942.5.
DR   RefSeq; YP_095831.1; NC_002942.5.
DR   AlphaFoldDB; Q5ZUJ3; -.
DR   SMR; Q5ZUJ3; -.
DR   STRING; 272624.lpg1805; -.
DR   PaxDb; Q5ZUJ3; -.
DR   PRIDE; Q5ZUJ3; -.
DR   EnsemblBacteria; AAU27884; AAU27884; lpg1805.
DR   GeneID; 66490937; -.
DR   KEGG; lpn:lpg1805; -.
DR   PATRIC; fig|272624.6.peg.1893; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   Proteomes; UP000000609; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..846
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224381"
FT   BINDING         610..617
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   846 AA;  94775 MW;  0EFC9EF6E206EC62 CRC64;
     MASSHTPMMQ QYLRIKTDYP DMLLFYRMGD FYELFFDDAK RASQLLDLTL THRGQSADKP
     IPMAGVPYHA VENYLARLLK KGESVAICEQ IGDPATSKGP VERQVTRIIT PGTVTDEALL
     DARKDNILLA IHTQKQKIGI AWVDLGGGRF HLQELTEEHQ LNAELVRLQP AELLCKESTP
     LPSFCSNFAV KFRPGWEFDA SNAHKLLCEQ FSVTDLSAFG EQNYPTALIA AGALLAYLKT
     TQKQSLPHLT TLTLEQSEDY LQLDASTQKH LELFENIHGG GEHCLLSILD KTACAMGSRL
     LKRWLGKPLK QHAIIQTRQQ AIKEIIFLQQ DVSLHQLIKQ CADVERIVSR IALKSARPRD
     LVSLLQTLTL LPAIHDELQE NKSLLINEIK KEISPLPLLQ QLLETAIIDN PPMLIRDGGV
     IAPGFDEELD ELRNLSSNAH ETLVKLEQEE KNRTGLSTLK LGYNSVQGFY IELSKAQAQN
     APPHFHRKQT LKNVERYITP ELKLFEDKVL SAQSKALARE KWLYDNLLEE IQQYIPELSD
     LAKSLAQLDV LVTLAERAQS LNWNCPNLVP ESGIMIQAGR HPVIEPLLQE RFIANDLELK
     PNQNMLLITG PNMGGKSTYM RQTALIVLLA HIGSFVPADK VTLGPLDRIF TRIGASDDLS
     SGRSTFMVEM TETAQILRQA TSQSLVLIDE IGRGTSTYDG MALAYASCAF LASTIKAYTL
     FSTHYLELTE LPKEFSCIRN VHLQASIKTG QIVFLYRVEE GCANRSYGLE VAELAGIPKE
     VLKLAHEHLN QIQDTQSILV QTQIIKPPTS PVLTELKKID PDRLTAKEAL DLIYKLKHLE
     CAESIN