ID   MUTS_LEGPL              Reviewed;         846 AA.
AC   Q5WVP6;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=lpl1769;
OS   Legionella pneumophila (strain Lens).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales;
OC   Legionellaceae; Legionella.
OX   NCBI_TaxID=297245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Lens;
RX   PubMed=15467720; DOI=10.1038/ng1447;
RA   Cazalet C., Rusniok C., Brueggemann H., Zidane N., Magnier A., Ma L.,
RA   Tichit M., Jarraud S., Bouchier C., Vandenesch F., Kunst F., Etienne J.,
RA   Glaser P., Buchrieser C.;
RT   "Evidence in the Legionella pneumophila genome for exploitation of host
RT   cell functions and high genome plasticity.";
RL   Nat. Genet. 36:1165-1173(2004).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CR628337; CAH16008.1; -; Genomic_DNA.
DR   RefSeq; WP_011215778.1; NC_006369.1.
DR   AlphaFoldDB; Q5WVP6; -.
DR   SMR; Q5WVP6; -.
DR   EnsemblBacteria; CAH16008; CAH16008; lpl1769.
DR   KEGG; lpf:lpl1769; -.
DR   LegioList; lpl1769; -.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000002517; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..846
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224379"
FT   BINDING         610..617
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   846 AA;  94934 MW;  A1FBB86A6F8C7A91 CRC64;
     MASSHTPMMQ QYLRIKTDYP DMLLFYRMGD FYELFFDDAK RASQLLDLTL THRGQSADKP
     IPMAGVPYHA VENYLARLLK KGESVAICEQ IGDPATSKGP VERQVTRIIT PGTVTDEALL
     DARKDNILLA IHTQKQKIGI AWVDLGGGRF HLQELTEEHQ LNAELVRLQP AELLCKESTP
     LPSFCSNFAV KFRPGWEFDA SNAHKLLCEQ FSVTDLSAFG EQNYPTALIA AGALLAYLKT
     TQKQSLPHLT TLTLEQSEDY LQLDASTQRH LELFENIHGG GEHCLLSILD KTACAMGSRL
     LKRWLGKPLK QHAIIQTRQQ AIKEIIFLQQ DVSLHQLIKQ CADVERIVSR IALKSARPRD
     LVSLLQTLIL LPAIHDELQE NKTLLINEIK KEISPLPLLQ QLLETAIIDN PPMLIRDGGV
     IAPGFDEELD ELRNLSSNAH ETLVKLEQEE KNRTGLSTLK LGYNSVQGFY IELSKAQAQN
     APPHFHRKQT LKNVERYITP ELKLFEDKVL SAQSKALARE KWLYDNLLEE IQQYIPELSD
     LAKSLAQLDV LVTLTERAQS LNWNCPNLVP ESGIMIQAGR HPVIEPLLQE RFIANDLELK
     PNQNMLLITG PNMGGKSTYM RQTALIVLLA HIGSFVPADE VRLGPLDRIF TRIGASDDLS
     SGRSTFMVEM TETAQILRQA TSQSLVLIDE IGRGTSTYDG MALAYASCAF LASTIKAYTL
     FSTHYLELTE LPKDFSCIRN VHLQASIKTG QIVFLYRVEE GCANRSYGLE VAELAGIPKE
     VLKLAHEHLN QIQDTQSILV QTQIIKPPTS PILTELKKID PDRLTAKEAL DLIYKLKQLE
     CVESIN