ID   MUTS_LEPBL              Reviewed;         848 AA.
AC   Q051T9;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=LBL_1417;
OS   Leptospira borgpetersenii serovar Hardjo-bovis (strain L550).
OC   Bacteria; Spirochaetes; Leptospirales; Leptospiraceae; Leptospira.
OX   NCBI_TaxID=355276;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=L550;
RX   PubMed=16973745; DOI=10.1073/pnas.0603979103;
RA   Bulach D.M., Zuerner R.L., Wilson P., Seemann T., McGrath A., Cullen P.A.,
RA   Davis J., Johnson M., Kuczek E., Alt D.P., Peterson-Burch B., Coppel R.L.,
RA   Rood J.I., Davies J.K., Adler B.;
RT   "Genome reduction in Leptospira borgpetersenii reflects limited
RT   transmission potential.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:14560-14565(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000348; ABJ78906.1; -; Genomic_DNA.
DR   RefSeq; WP_011670112.1; NC_008508.1.
DR   AlphaFoldDB; Q051T9; -.
DR   SMR; Q051T9; -.
DR   KEGG; lbl:LBL_1417; -.
DR   PATRIC; fig|355276.3.peg.1789; -.
DR   HOGENOM; CLU_002472_3_1_12; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..848
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000008072"
FT   BINDING         605..612
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   848 AA;  97354 MW;  F62841CFE7B67DF7 CRC64;
     MNLEITGTSA EYWSDLAEAL NTPMMKQFLT IKKDFPDTIL FFRMGDFYEM FLEDAKIASS
     ILDIALTKRQ NAVPMCGIPY HSKDNYISRL LNAGKKIAIC EQSKPEETGS KLMTRDVVRI
     ITPGTVIEEN LLTGFQNNYL AVLHLKKSLI YFAMADFSTG ELFYSSTPIT SLEKLVAELE
     KFRPSEICVP QSELSFFQEL EYFRDKEFTV LKDQPEIPEK DQFQILSRYL DEYIRETYRD
     NKLVLREPRI LSSGKFLEMD RETILNLELV ENGKEKNHTL YSIFNFCNTA KGKRLLKQRI
     LFPECDPMVL YSRWEKQDIL FKIVLAPFIA ALRDVGDIER ILTRFRGNHS YPRDFRSILN
     SISTGIKLKK ELEALSYPFL IPLEELKVLS EFIEERLHPG DDLPVILGNG PFLKTGFSTR
     LDKAREAGFK GKDWILSLEA EEKKRTNLNT LKIRYNKIVG YFIEISRAQA EQAPKDYLKK
     QTLVGSERFT TPKLEEIERT ILEADEIIQE IERAEFNRMV EEVLKYSSAL LSFSEEIGDL
     DFQISVLIAK DKFGWIRPEL SKDRSLNLVD SRHPVVEATL PPGQEFVPNS VYLDTQNQAI
     AVLTGPNMAG KSTFMRQIAL NQILFQMGAF VPAKSARLPI VDKLFTRIGA GDNLTAGEST
     FYVEMKETAN ILNHYTEDSL ILFDEVGRGT STYDGMSIAW SILEYLSSLS VKPKTIFATH
     YHELTELSRL SGIFNLYLET LEKEDKVLFL RKVKVGKAKK SFGIYVAKIA GIPEPIVKRA
     AELLIDLESK KKEIRIQEAQ PTLFIEPESK NLPSETEESI LKLKLEEMTP MEALKKLEDF
     QKKLRKQK