MUTS_LEPIC
ID MUTS_LEPIC Reviewed; 848 AA.
AC P61669;
DT 07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2004, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=LIC_11774;
OS Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni
OS (strain Fiocruz L1-130).
OC Bacteria; Spirochaetes; Leptospirales; Leptospiraceae; Leptospira.
OX NCBI_TaxID=267671;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Fiocruz L1-130;
RX PubMed=15028702; DOI=10.1128/jb.186.7.2164-2172.2004;
RA Nascimento A.L.T.O., Ko A.I., Martins E.A.L., Monteiro-Vitorello C.B.,
RA Ho P.L., Haake D.A., Verjovski-Almeida S., Hartskeerl R.A., Marques M.V.,
RA Oliveira M.C., Menck C.F.M., Leite L.C.C., Carrer H., Coutinho L.L.,
RA Degrave W.M., Dellagostin O.A., El-Dorry H., Ferro E.S., Ferro M.I.T.,
RA Furlan L.R., Gamberini M., Giglioti E.A., Goes-Neto A., Goldman G.H.,
RA Goldman M.H.S., Harakava R., Jeronimo S.M.B., Junqueira-de-Azevedo I.L.M.,
RA Kimura E.T., Kuramae E.E., Lemos E.G.M., Lemos M.V.F., Marino C.L.,
RA Nunes L.R., de Oliveira R.C., Pereira G.G., Reis M.S., Schriefer A.,
RA Siqueira W.J., Sommer P., Tsai S.M., Simpson A.J.G., Ferro J.A.,
RA Camargo L.E.A., Kitajima J.P., Setubal J.C., Van Sluys M.A.;
RT "Comparative genomics of two Leptospira interrogans serovars reveals novel
RT insights into physiology and pathogenesis.";
RL J. Bacteriol. 186:2164-2172(2004).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR EMBL; AE016823; AAS70363.1; -; Genomic_DNA.
DR RefSeq; WP_001047644.1; NC_005823.1.
DR AlphaFoldDB; P61669; -.
DR SMR; P61669; -.
DR PaxDb; P61669; -.
DR EnsemblBacteria; AAS70363; AAS70363; LIC_11774.
DR GeneID; 61141672; -.
DR KEGG; lic:LIC_11774; -.
DR HOGENOM; CLU_002472_3_1_12; -.
DR OMA; TPMMAQY; -.
DR Proteomes; UP000007037; Chromosome I.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.420.110; -; 1.
DR Gene3D; 3.40.1170.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361; PTHR11361; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; SSF48334; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF53150; SSF53150; 1.
DR SUPFAM; SSF55271; SSF55271; 1.
DR TIGRFAMs; TIGR01070; mutS1; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT CHAIN 1..848
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_0000115106"
FT BINDING 605..612
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 848 AA; 97209 MW; 1169A8DC62F836A4 CRC64;
MNLESTATSA EYWSDLADAL NTPMMKQFLA IKKDFPDTIL FFRMGDFYEM FLEDAKIASS
ILDIALTKRQ NAVPMCGIPY HSKDNYISRL LNAGKKIAIC EQSKPEEAGS KLMTRDVVRI
ITPGTVIEEN LLSGFQNNYL AVLHLKKSLI YFAIADFSTG EVFYSSVSVT GLERLIAELE
KFKPSEICVP KSEHTFFQEL EYFKNREFTV LKNQIETSEK DSFQVLSKYL NEYIRETYRD
NKLVLREPKI LSSGKFLEMD RETIRNLELV ENEKEKNNTL YSIFNFCNTA KGKRLLKQRI
LFPECDPVVL YSRWEKQDIL LKTVLAPYIT ALKDFGDLER ILTRFRGNHA YPRDFRSLLN
SISSGIKLKE ELEKVSYPFL IPIEELKKIS DFIQERLHPG DDLPVILGNG IFLKKGFSQK
LDQAREAGVK GKDWILDLET KEKKRTGLNT LKIRYNKIVG YFIEISRAQA EQAPKDYLKK
QTLVGSERFT MPKLEEIERT ILEADEIIQE IERTEFNRMV EEVLKFSSSL LSFSEEIGDL
DFQISLLTAK DKFGWIRPKL SEDRSLDLND SRHPVVEATL PPGQEFIPNS VYLDTQDKAI
AVLTGPNMAG KSTFMRQIAL NQILFQIGAF VPAKSAKLPI VDKLFTRIGA GDNLTAGEST
FFVEMKETAN ILNHYTEDSL ILFDEVGRGT STYDGMSIAW SILEYLSSLS VRPKTIFATH
YHELTELSRL GGIFNLYLET LEKEDRVLFL RKVKVGKAKK SFGIYVAKIA GVPEPIVKRA
AELLTDLESK KKEIKIQEAQ PTLFTEPETK NFNSQTEESI LKLKLEEMTP IEALKTLEDF
QKKLRKQK