ID   MUTS_LEPIN              Reviewed;         848 AA.
AC   Q8F496;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; Synonyms=mutS1;
GN   OrderedLocusNames=LA_2146;
OS   Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain
OS   56601).
OC   Bacteria; Spirochaetes; Leptospirales; Leptospiraceae; Leptospira.
OX   NCBI_TaxID=189518;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=56601;
RX   PubMed=12712204; DOI=10.1038/nature01597;
RA   Ren S.-X., Fu G., Jiang X.-G., Zeng R., Miao Y.-G., Xu H., Zhang Y.-X.,
RA   Xiong H., Lu G., Lu L.-F., Jiang H.-Q., Jia J., Tu Y.-F., Jiang J.-X.,
RA   Gu W.-Y., Zhang Y.-Q., Cai Z., Sheng H.-H., Yin H.-F., Zhang Y., Zhu G.-F.,
RA   Wan M., Huang H.-L., Qian Z., Wang S.-Y., Ma W., Yao Z.-J., Shen Y.,
RA   Qiang B.-Q., Xia Q.-C., Guo X.-K., Danchin A., Saint Girons I.,
RA   Somerville R.L., Wen Y.-M., Shi M.-H., Chen Z., Xu J.-G., Zhao G.-P.;
RT   "Unique physiological and pathogenic features of Leptospira interrogans
RT   revealed by whole-genome sequencing.";
RL   Nature 422:888-893(2003).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AE010300; AAN49345.1; -; Genomic_DNA.
DR   RefSeq; NP_712327.1; NC_004342.2.
DR   RefSeq; WP_001047648.1; NC_004342.2.
DR   AlphaFoldDB; Q8F496; -.
DR   SMR; Q8F496; -.
DR   STRING; 189518.LA_2146; -.
DR   EnsemblBacteria; AAN49345; AAN49345; LA_2146.
DR   KEGG; lil:LA_2146; -.
DR   PATRIC; fig|189518.3.peg.2138; -.
DR   HOGENOM; CLU_002472_3_1_12; -.
DR   InParanoid; Q8F496; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000001408; Chromosome I.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0030983; F:mismatched DNA binding; IBA:GO_Central.
DR   GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..848
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115107"
FT   BINDING         605..612
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   848 AA;  97182 MW;  3A8C11D05D3BC6A1 CRC64;
     MNLESTATSA EYWSDLADAL NTPMMKQFLA IKKDFPDTIL FFRMGDFYEM FLEDAKIASS
     ILDIALTKRQ NAVPMCGIPY HSKDNYISRL LNAGKKIAIC EQSKPEEAGS KLMTRDVVRI
     ITPGTVIEEN LLSGFQNNYL AVLHLKKSLI YFAIADFSTG EVFYSSVSVT GLERLIAELE
     KFKPSEICVP KSEHTFFQEL EYFKNREFTV LKNQIETSEK DSFQVLSKYL NEYIRETYRD
     NKLVLREPKI LSSGKFLEMD RETIRNLELV ENEKEKNNTL YSIFNFCNTA KGKRLLKQRI
     LFPECDPVVL YSRWEKQDIL LKTVLAPYIT ALKDFGDLER ILTRFRGNHA YPRDFRSLLN
     SISSGIKLKE ELEKVSYPFL IPIEELKKIS DFIQERLHPG DDLPVILGNG IFLKKGFSQK
     LDQAREAGVK GKDWILDLET KEKKRTGLNT LKIRYNKIVG YFIEISRAQA EQAPKDYLKK
     QTLVGSERFT MPKLEEIERT ILEADEIIQE IERTEFNRMV EEVLKFSSSL LSFSEEIGDL
     DFQISLLTAK DKFGWIRPKL SEDRSLDLSD SRHPVVEATL PPGQEFIPNS VYLDTQDKAI
     AVLTGPNMAG KSTFMRQIAL NQILFQIGAF VPAKSAKLPI VDKLFTRIGA GDNLTAGEST
     FFVEMKETAN ILNHYTEDSL ILFDEVGRGT STYDGMSIAW SILEYLSSLS VRPKTIFATH
     YHELTELSRL GGIFNLYLET LEKEDRVLFL RKVKVGKAKK SFGIYVAKIA GVPEPIVKRA
     AELLTDLESK KKEIKIQEAQ PTLFTEPETK NFNSQTEESI LKLKLEEMTP IEALKTLEDF
     QKKLRKQK