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MUTS_LEUCK
ID   MUTS_LEUCK              Reviewed;         865 AA.
AC   B1N025;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=LCK_01303;
OS   Leuconostoc citreum (strain KM20).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Leuconostoc.
OX   NCBI_TaxID=349519;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KM20;
RX   PubMed=18281406; DOI=10.1128/jb.01862-07;
RA   Kim J.F., Jeong H., Lee J.-S., Choi S.-H., Ha M., Hur C.-G., Kim J.-S.,
RA   Lee S., Park H.-S., Park Y.-H., Oh T.K.;
RT   "Complete genome sequence of Leuconostoc citreum KM20.";
RL   J. Bacteriol. 190:3093-3094(2008).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; DQ489736; ACA83127.1; -; Genomic_DNA.
DR   RefSeq; WP_012305383.1; NC_010471.1.
DR   AlphaFoldDB; B1N025; -.
DR   SMR; B1N025; -.
DR   STRING; 349519.LCK_01303; -.
DR   EnsemblBacteria; ACA83127; ACA83127; LCK_01303.
DR   KEGG; lci:LCK_01303; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_9; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000002166; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..865
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000093634"
FT   BINDING         609..616
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   865 AA;  96019 MW;  A96A30AB1352388C CRC64;
     MGKIADTPMM VQYHEIKAQY PDAFVFYRLG DFYELFEEDA IQGAKILELT LTARNKNSEN
     PVPMAGIPHH AAQNYIDILV DQGYKVAIVE QMEDPAVAKG MVKRDVVQLV TPGTKMADGA
     GGDKQNNYLA AVLPAKNVWS IAYVDLSTGE LRATTTGRFE DVMDELSSLE VKEVVLSKND
     VATTEQQIAS QLGERGIVIS AQGTAEPSAT VSFLTQALKV TSEIEATTIL LNYIFDTQRR
     SLDHIVPATS YERLKFLKFN QDTRSNLDLV ENMRTKKKAG SLLGLIDRTN TAMGGRLLKQ
     WLLKPLRESS DIEARLDLVQ SFQNDFLTRG ALQDHLKSVY DLERLAARAA MGTMNARELV
     QLKRSLRAIP GIKSVLLQAD TTLSNAGQQL DDMTDLADLI DVAIVDEPPV SVREGNIIND
     GFDERIDGYR QVLKDNQQWL AQLEIDERAQ TGINSLKVGY NKNFGYYIEV TKANIGRLAT
     DRYQRLQTLT NAERFVTPAL KQHESLIIEA QAKRTEREYE LFVTVREHVK SDISRIQTLA
     QHIARLDVLS SLADVADNQR FVRPTFTNQH VIHIMQGRHP VVESILDAGD FVANDVILDE
     SINMQLITGP NMAGKSTYMR ELALIVILAQ MGSFVPADVA ELPIFDQIFT RIGANDDMAM
     GQSTFMVEMA EANDALQQAT ANSLVLFDEL GRGTATYDGM ALAQAIIEFL DKHIHAKTLF
     STHYHELTVL ADNHTSIENV HVGAVEDDEG QLHFLHQIQS GPADKSYGIH VAALAGLPKE
     LIDNATSILH DLEAGKMIVT QTNDQVASAV IQPDAHLSEQ VALFDMTVTD DKTQKILDAL
     DNYDILNMTP VDAINALNRL KKMRS
 
 
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