MUTS_LEUCK
ID MUTS_LEUCK Reviewed; 865 AA.
AC B1N025;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 1.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=LCK_01303;
OS Leuconostoc citreum (strain KM20).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC Leuconostoc.
OX NCBI_TaxID=349519;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KM20;
RX PubMed=18281406; DOI=10.1128/jb.01862-07;
RA Kim J.F., Jeong H., Lee J.-S., Choi S.-H., Ha M., Hur C.-G., Kim J.-S.,
RA Lee S., Park H.-S., Park Y.-H., Oh T.K.;
RT "Complete genome sequence of Leuconostoc citreum KM20.";
RL J. Bacteriol. 190:3093-3094(2008).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR EMBL; DQ489736; ACA83127.1; -; Genomic_DNA.
DR RefSeq; WP_012305383.1; NC_010471.1.
DR AlphaFoldDB; B1N025; -.
DR SMR; B1N025; -.
DR STRING; 349519.LCK_01303; -.
DR EnsemblBacteria; ACA83127; ACA83127; LCK_01303.
DR KEGG; lci:LCK_01303; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_4_0_9; -.
DR OMA; TPMMAQY; -.
DR OrthoDB; 15991at2; -.
DR Proteomes; UP000002166; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.420.110; -; 1.
DR Gene3D; 3.40.1170.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361; PTHR11361; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; SSF48334; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF53150; SSF53150; 1.
DR SUPFAM; SSF55271; SSF55271; 1.
DR TIGRFAMs; TIGR01070; mutS1; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT CHAIN 1..865
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_1000093634"
FT BINDING 609..616
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 865 AA; 96019 MW; A96A30AB1352388C CRC64;
MGKIADTPMM VQYHEIKAQY PDAFVFYRLG DFYELFEEDA IQGAKILELT LTARNKNSEN
PVPMAGIPHH AAQNYIDILV DQGYKVAIVE QMEDPAVAKG MVKRDVVQLV TPGTKMADGA
GGDKQNNYLA AVLPAKNVWS IAYVDLSTGE LRATTTGRFE DVMDELSSLE VKEVVLSKND
VATTEQQIAS QLGERGIVIS AQGTAEPSAT VSFLTQALKV TSEIEATTIL LNYIFDTQRR
SLDHIVPATS YERLKFLKFN QDTRSNLDLV ENMRTKKKAG SLLGLIDRTN TAMGGRLLKQ
WLLKPLRESS DIEARLDLVQ SFQNDFLTRG ALQDHLKSVY DLERLAARAA MGTMNARELV
QLKRSLRAIP GIKSVLLQAD TTLSNAGQQL DDMTDLADLI DVAIVDEPPV SVREGNIIND
GFDERIDGYR QVLKDNQQWL AQLEIDERAQ TGINSLKVGY NKNFGYYIEV TKANIGRLAT
DRYQRLQTLT NAERFVTPAL KQHESLIIEA QAKRTEREYE LFVTVREHVK SDISRIQTLA
QHIARLDVLS SLADVADNQR FVRPTFTNQH VIHIMQGRHP VVESILDAGD FVANDVILDE
SINMQLITGP NMAGKSTYMR ELALIVILAQ MGSFVPADVA ELPIFDQIFT RIGANDDMAM
GQSTFMVEMA EANDALQQAT ANSLVLFDEL GRGTATYDGM ALAQAIIEFL DKHIHAKTLF
STHYHELTVL ADNHTSIENV HVGAVEDDEG QLHFLHQIQS GPADKSYGIH VAALAGLPKE
LIDNATSILH DLEAGKMIVT QTNDQVASAV IQPDAHLSEQ VALFDMTVTD DKTQKILDAL
DNYDILNMTP VDAINALNRL KKMRS