MUTS_LEVBA
ID MUTS_LEVBA Reviewed; 892 AA.
AC Q03R33;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 14-NOV-2006, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=LVIS_1233;
OS Levilactobacillus brevis (strain ATCC 367 / BCRC 12310 / CIP 105137 / JCM
OS 1170 / LMG 11437 / NCIMB 947 / NCTC 947) (Lactobacillus brevis).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC Levilactobacillus.
OX NCBI_TaxID=387344;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 367 / BCRC 12310 / CIP 105137 / JCM 1170 / LMG 11437 / NCIMB
RC 947 / NCTC 947;
RX PubMed=17030793; DOI=10.1073/pnas.0607117103;
RA Makarova K.S., Slesarev A., Wolf Y.I., Sorokin A., Mirkin B., Koonin E.V.,
RA Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V.,
RA Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M.,
RA Hawkins T., Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A.,
RA Baldwin K., Lee J.-H., Diaz-Muniz I., Dosti B., Smeianov V., Wechter W.,
RA Barabote R., Lorca G., Altermann E., Barrangou R., Ganesan B., Xie Y.,
RA Rawsthorne H., Tamir D., Parker C., Breidt F., Broadbent J.R., Hutkins R.,
RA O'Sullivan D., Steele J., Unlu G., Saier M.H. Jr., Klaenhammer T.,
RA Richardson P., Kozyavkin S., Weimer B.C., Mills D.A.;
RT "Comparative genomics of the lactic acid bacteria.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR EMBL; CP000416; ABJ64339.1; -; Genomic_DNA.
DR RefSeq; WP_011667969.1; NC_008497.1.
DR AlphaFoldDB; Q03R33; -.
DR SMR; Q03R33; -.
DR STRING; 387344.LVIS_1233; -.
DR EnsemblBacteria; ABJ64339; ABJ64339; LVIS_1233.
DR KEGG; lbr:LVIS_1233; -.
DR PATRIC; fig|387344.15.peg.1172; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_3_1_9; -.
DR OMA; TPMMAQY; -.
DR OrthoDB; 15991at2; -.
DR Proteomes; UP000001652; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.420.110; -; 1.
DR Gene3D; 3.40.1170.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361; PTHR11361; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; SSF48334; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF53150; SSF53150; 1.
DR SUPFAM; SSF55271; SSF55271; 1.
DR TIGRFAMs; TIGR01070; mutS1; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..892
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_1000008066"
FT REGION 796..842
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 796..818
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 607..614
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 892 AA; 98864 MW; D3F9652F85AAA4BB CRC64;
MTKTSTTPMM EQYQKIKDQY PDAFLFYRLG DFYEMFNEDA VKGSQLLELT LTTRSHSAKN
PIPMCGVPHK AVQSYIDILV DQGYKVAICE QMEDPKLAKG MVKREVIQLV TPGTQTDTGA
AGAKRNNYLT ALTLADSGEY GLAYTDLSTG ELKAAAITGE DAVLNELMSL QTKEVVVDTT
VAEGLRQRMK QLGMMISTQD AIQTSSEISY VEQDLTTDLL RQVVGVLVTY VTVTQKRSLA
HLQRAVVYQP TAFLKMDHAS QTNLELTQNL RTKKKSGTLL WLLDETKTAM GGRLLKQWLD
RPLIDRQQIE NRQARVAALL DHYFERNSLQ EELVKVYDLE RLAGRVAFGS VNGRDLIQLQ
TSLEQVPQIQ HTIEELDEPV FDTTLAGLDP VSDVADAIRA AIVPEPPLSV ADGGVIRDGF
NAQLDEYRDA MRNGKTWLAE LEAHEREVTG INNLKIGYNH VFGYYIEVTK VNLSKLPADR
YERKQTLTNA ERFSTPELKE KERLILEAEE KSVALEYKLF VELREQVKAA ITRLQKLAAV
IASLDVLQSF AVVSEDYHFV QPKLVSGHQL KITQGRHPVV EKVLGRQSYV PNDVTMDDQT
NILLITGPNM SGKSTYMRQL ALTVIMAQMG CFVPAEAAEM PIFDQIFTRI GAADDLISGQ
STFMVEMQEA NRALSHATAN SLILFDEIGR GTATYDGMAL AQAIIEYVHN RVHAKTLFST
HYHELTALDE SLKQLKNVHV GAVERDGDLV FLHQMQPGPA DKSYGIHVAK LAGMPTKLLQ
RAEVILTDLE QSAANQPAAA ASQSSSAPAE SAQAPVSDSV VAQDVAASAP EPQEKATAIS
ETDQQLSLFS DAPELSPAQA KVLEQISQLN LMGMTPMAIM NQVYQWQQKL TK
