ID   MUTS_LIGS1              Reviewed;         876 AA.
AC   Q1WT15;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=LSL_1128;
OS   Ligilactobacillus salivarius (strain UCC118) (Lactobacillus salivarius).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Ligilactobacillus.
OX   NCBI_TaxID=362948;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UCC118;
RX   PubMed=16617113; DOI=10.1073/pnas.0511060103;
RA   Claesson M.J., Li Y., Leahy S., Canchaya C., van Pijkeren J.P.,
RA   Cerdeno-Tarraga A.M., Parkhill J., Flynn S., O'Sullivan G.C., Collins J.K.,
RA   Higgins D., Shanahan F., Fitzgerald G.F., van Sinderen D., O'Toole P.W.;
RT   "Multireplicon genome architecture of Lactobacillus salivarius.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:6718-6723(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000233; ABD99936.1; -; Genomic_DNA.
DR   RefSeq; WP_011476178.1; NC_007929.1.
DR   RefSeq; YP_536019.1; NC_007929.1.
DR   AlphaFoldDB; Q1WT15; -.
DR   SMR; Q1WT15; -.
DR   STRING; 362948.LSL_1128; -.
DR   PRIDE; Q1WT15; -.
DR   EnsemblBacteria; ABD99936; ABD99936; LSL_1128.
DR   KEGG; lsl:LSL_1128; -.
DR   PATRIC; fig|362948.14.peg.1201; -.
DR   HOGENOM; CLU_002472_1_3_9; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000006559; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..876
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000008069"
FT   REGION          801..825
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        802..821
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         609..616
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   876 AA;  99449 MW;  D36B9A5495443AFE CRC64;
     MPQKTKQTPM MEQYMQIKKQ YPDAFLFYRL GDFYEMFYDD AIKGSQILEL TLTQRNKKAV
     DPIPMCGVPH HAAQNYIDIL VDKGYKVAIC EQVEDPKQAK GMVKREVIQL VTPGTIIDES
     AGEAKENNYL TALHFENDQY GFAYVDLSTG ELKVSVLNTI DTILNELISL RTKEIVVDSS
     VNDDVLNQIK NLKILISEQN DTEDSSEVSF ASQDVENSVE VEVIKHLITY LKITQKRALS
     HLQRAVHYEP SQYLKMDYHA KRNLELLRNL RTQKKSGTLL WLLDSTKTAM GGRLLKQWID
     RPLINLKEIE ARQSMVENLL THYFERSGLQ EELVNVYDLE RLAGKVAFGS VNGRDLIQLR
     TSLEHIPQIR YIIQELNDDG TFDEIFDKLD PIEDIADLIE QAIEDEPPIS VTDGNLIKPG
     YSQELDEYVD AMKNGKAWLA ELEAKERQAT GINNLKIGFN RVFGYYIEVS KGNLSKLPED
     RYQRKQTLTN AERFITPELK EKESLILGAE SKAKELEYKI FTGIRDQIKD EIQRIQELAG
     AVAALDVLQS FATVSEQGHF VKPELTTDNH SLDIKDGWHP VVEKVMGKQS YIPNDIKMDD
     DLDVLLITGP NMSGKSTYMR QLALTVVIAQ IGCFVPAKSA KMPIFDQIFT RIGAADDLIS
     GESTFMVEMK ETNVALMNAT RNSLLLFDEI GRGTATYDGM ALAQAIIEYV HNNIHAKTLF
     STHYHELTIL DESLDKLQNV HVGAIEKNGE LIFLHKMQEG PADKSYGIHV AKLAGMPDKL
     LKRADSILNK LESENDFTVD STESYAEEKH IEEKNENETS EIQEEQLSLF QPEAVSLDSN
     QSKILKEIKN ANLMGMTPMD VMNIVFKWQK ELNKKG